Evidence map›Paper›PMID 30275051›Full record

ArticleCancer research2018

Sexual Inequality in the Cancer Cell.

Arthur P Arnold, Christine M Disteche

Abstract readComment
In one paragraph

Article in Cancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Sex as an important factor in nanomedicine.Nature communications · 2021
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. X Inactivation and Escape: Epigenetic and Structural Features.Frontiers in cell and developmental biology · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Arthur P ArnoldDepartment of Integrative Biology & Physiology, and Laboratory of Neuroendocrinology of the Brain Research Institute, UCLA, Los Angeles, California. arnold@ucla.edu.
Christine M DistecheDepartments of Pathology and Medicine, University of Washington, Seattle, Washington.

Funding

Mouse X InactivationR01GM046883 · NIGMS · UNIVERSITY OF WASHINGTON · PI DISTECHE, CHRISTINE M. · 1992 to 2018
$5.9M
Genetic Mechanisms in Klinefelter Syndrome-Related BehaviorsR01HD076125 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P, JENTSCH, J. DAVID · 2014 to 2018
$2.3M
Molecular studies of sex chromosome aneuploidyR01GM113943 · NIGMS · UNIVERSITY OF WASHINGTON · PI DISTECHE, CHRISTINE M. · 2015 to 2018
$1.7M
Epigenetic regulation of myocardial ischemia/reperfusion injury by X chromosomeR01HL131182 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P, EGHBALI, MANSOUREH · 2016 to 2019
$1.5M
Discriminating sex chromosome and hormonal effects on brain sexual dimorphismsR21HD090637 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P, MACKENZIE-GRAHAM, ALLAN JAMES · 2017 to 2018
$428k
NHLBI NIH HHS R01 HL131182NICHD NIH HHS R01 HD076125NICHD NIH HHS R21 HD090637NIGMS NIH HHS R01 GM046883NIGMS NIH HHS R01 GM113943
6 · The paper itself

Abstract

Investigating sex differences in cancer will improve therapy for both sexes and discover sex-specific protective mechanisms. Two recent analyses by Lopes-Ramos and colleagues and Li and colleagues point to specific gene regulatory networks and genomic alterations associated with sex differences in tumor incidence and progression. Integrating this information with emerging concepts about sex biases in the genome may help focus attention on factors that shift the odds for tumor growth.

Indexed as

OncogenesBiomarkersFemaleHumansMaleNeoplasmsSex CharacteristicsSocioeconomic FactorsBiomarkers

Identifiers

PMID30275051
PMCPMC6204258

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.