Evidence map›Paper›PMID 30275043›Full record

ReviewGenes & development2018

Roles of the immune system in cancer: from tumor initiation to metastatic progression.

Hugo Gonzalez, Catharina Hagerling, Zena Werb

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06625203 (Multi Omics and Spatial Atlas In Cancer), which is not on this map. Cited by 1,253 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,253citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06625203 recruitingnot on this mapstarted 2023, after this paper: background citation

Multi Omics and Spatial Atlas In Cancer

TypeobservationalSponsorOWKINRan2023 to 2028Enrolled7,000ConditionsDiffuse Large B Cell Lymphoma, Solid Tumor Cancer
3 · Its place in the literature

Who cites it

1,253 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  3. Interaction of HIF-1a with various cell death pathways in tumor immune microenvironment (TIME).Apoptosis : an international journal on programmed cell death · 2026
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1,193 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hugo GonzalezDepartment of Anatomy, the Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA.
Catharina HagerlingDepartment of Anatomy, the Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA.
Zena WerbDepartment of Anatomy, the Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA.ORCID 0000-0002-6525-3872

Funding

Role of Metalloproteinases in Mammary Gland RemodelingR01CA057621 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WERB, ZENA · 1993 to 2017
$9.0M
Integrative approach to heterogeneity in breast cancer metastasisU01CA199315 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI, SPELLMAN, PAUL T. · 2016 to 2020
$3.2M
Role of GATA3 in transcriptional pathways suppressing breast cancer metastasisR01CA190851 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WERB, ZENA · 2015 to 2019
$2.0M
NCI NIH HHS R01 CA057621NCI NIH HHS R01 CA190851NCI NIH HHS U01 CA199315
6 · The paper itself

Abstract

The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms that mimic peripheral immune tolerance in order to avoid tumoricidal attack. Here, we provide an update of recent accomplishments, unifying concepts, and future challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas.

Indexed as

B-LymphocytesCarcinomaDendritic CellsDisease ProgressionHumansImmunologic SurveillanceInflammationKiller Cells, NaturalMacrophagesNeoplasm MetastasisNeoplasmsNeutrophilsT-Lymphocytescancer heterogeneitydisseminated tumor cellsimmune cross-talkmetastasis-associated immune cellspatient-derived xenografttumor-associated macrophages

Identifiers

PMID30275043
PMCPMC6169832

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.