Evidence map›Paper›PMID 30275010›Full record

ArticleInfection and immunity2018

Deletion of Interleukin-4 Receptor Alpha-Responsive Keratinocytes in BALB/c Mice Does Not Alter Susceptibility to Cutaneous Leishmaniasis.

Melissa Govender, Ramona Hurdayal, Berenice Martinez-Salazar, Kaya Gqada, Shandre Pillay, Lorna Gcanga, Katiuska Passelli, Natalie E Nieuwenhuizen, Fabienne Tacchini-Cottier, Reto Guler and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Biomedicines · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

Melissa Govender *International Center for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa.ORCID 0000-0001-8327-5517
Ramona Hurdayal *International Center for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa.
Berenice Martinez-SalazarInternational Center for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa.
Kaya GqadaInternational Center for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa.
Shandre PillayInternational Center for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa.
Lorna GcangaInternational Center for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa.
Katiuska PasselliDepartment of Biochemistry, and WHO Immunology Research and Training Collaborative Center, University of Lausanne, Epalinges, Switzerland.
Natalie E NieuwenhuizenInternational Center for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa.
Fabienne Tacchini-CottierDepartment of Biochemistry, and WHO Immunology Research and Training Collaborative Center, University of Lausanne, Epalinges, Switzerland.
Reto GulerInternational Center for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa Reto.Guler@uct.ac.za frank.brombacher@icgeb.org.
Frank BrombacherInternational Center for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa Reto.Guler@uct.ac.za frank.brombacher@icgeb.org.
South African Medical Research Council · ZAUniversity of Lausanne · CHLinköping University · SE

Funding

Wellcome Trust 203135Z/16/Z
6 · The paper itself

Abstract

The skin microenvironment at the site of infection plays a role in the early events that determine protective T helper 1/type 1 immune responses during cutaneous leishmaniasis (CL) infection. During CL in nonhealing BALB/c mice, early interleukin-4 (IL-4) can instruct dendritic cells for protective Th1 immunity. Additionally, keratinocytes, which are the principal cell type in the skin epidermis, have been shown to secrete IL-4 early after

Indexed as

Gene DeletionAnimalsAutocrine CommunicationCD4-Positive T-LymphocytesDisease SusceptibilityFemaleInterleukin-13Interleukin-4 Receptor alpha SubunitKeratinocytesLeishmania majorLeishmaniasis, CutaneousMaleMiceMice, Inbred BALB CMice, KnockoutParacrine CommunicationInterleukin-13Interleukin-4 Receptor alpha SubunitIL-4 receptor alpha signalingkeratinocytesLeishmania majorskin

Identifiers

PMID30275010
PMCPMC6246911
OpenAlexW2894908601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.