ArticleGenetics2018
Replicability of Introgression Under Linked, Polygenic Selection.
Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Adaptive introgression between two Drosophila species enhances heat tolerance despite barriers to gene flow.PLoS biology · 2026Article
- Limited Selection on Neanderthal DNA in 30,780 Recently Admixed Genomes with African-like Ancestry.Molecular biology and evolution · 2026Article
- Introgression of thermal tolerance alleles drives adaptation despite risk of mitonuclear conflict.Molecular biology and evolution · 2026Article
- PolyAdapt: Characterizing Polygenic Adaptive Architectures in the Presence of Strong Linkage Disequilibrium.Genome biology and evolution · 2026Article
- Introgression and Divergence in a Young Species Group.Molecular ecology · 2026Article
- Reduced Parallel Gene Expression Evolution With Increasing Genetic Divergence-A Hallmark of Polygenic Adaptation.Molecular ecology · 2025Article
- The fitness of an introgressing haplotype changes over the course of divergence and depends on its size and genomic location.PLoS biology · 2023Article
- How predictable is adaptation from standing genetic variation? Experimental evolution inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Rapid and predictable genome evolution across three hybrid ant populations.PLoS biology · 2022Article
- Reproductive isolation via polygenic local adaptation in sub-divided populations: Effect of linkage disequilibria and drift.PLoS genetics · 2022Article
- Hybrid fitness effects modify fixation probabilities of introgressed alleles.G3 (Bethesda, Md.) · 2022Article
- Article
- An Experimental Test of Adaptive Introgression in Locally Adapted Populations of Splash Pool Copepods.Molecular biology and evolution · 2021Article
- Detecting selected haplotype blocks in evolve and resequence experiments.Molecular ecology resources · 2021Article
- Tapping Diversity From the Wild: From Sampling to Implementation.Frontiers in plant science · 2021Review
- Polygenic adaptation: a unifying framework to understand positive selection.Nature reviews. Genetics · 2020Review
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
We study how a block of genome with a large number of weakly selected loci introgresses under directional selection into a genetically homogeneous population. We derive exact expressions for the expected rate of growth of any fragment of the introduced block during the initial phase of introgression, and show that the growth rate of a single-locus variant is largely insensitive to its own additive effect, but depends instead on the combined effect of all loci within a characteristic linkage scale. The expected growth rate of a fragment is highly correlated with its long-term introgression probability in populations of moderate size, and can hence identify variants that are likely to introgress across replicate populations. We clarify how the introgression probability of an individual variant is determined by the interplay between hitchhiking with relatively large fragments during the early phase of introgression and selection on fine-scale variation within these, which at longer times results in differential introgression probabilities for beneficial and deleterious loci within successful fragments. By simulating individuals, we also investigate how introgression probabilities at individual loci depend on the variance of fitness effects, the net fitness of the introduced block, and the size of the recipient population, and how this shapes the net advance under selection. Our work suggests that even highly replicable substitutions may be associated with a range of selective effects, which makes it challenging to fine map the causal loci that underlie polygenic adaptation.
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