Evidence map›Paper›PMID 30274882›Full record

ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2019

Surgical resection of lymph node positive intrahepatic cholangiocarcinoma may not improve survival.

Scott Kizy, Ariella M Altman, Schelomo Marmor, Keith Wirth, Jane Y Ching Hui, Todd M Tuttle, Jason W Denbo, Eric H Jensen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Racial and Ethnic Disparities in Survival among Patients with Cholangiocarcinoma in the United States: A Systematic Review and Meta-analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
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  13. Cholangiocarcinoma.Nature reviews. Disease primers · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Scott KizyDivision of Surgical Oncology, Department of Surgery, University of Minnesota, USA.
Ariella M AltmanDivision of Surgical Oncology, Department of Surgery, University of Minnesota, USA.
Schelomo MarmorDivision of Surgical Oncology, Department of Surgery, University of Minnesota, USA.
Keith WirthDivision of Surgical Oncology, Department of Surgery, University of Minnesota, USA.
Jane Y Ching HuiDivision of Surgical Oncology, Department of Surgery, University of Minnesota, USA.
Todd M TuttleDivision of Surgical Oncology, Department of Surgery, University of Minnesota, USA.
Jason W DenboDivision of Surgical Oncology, Department of Surgery, University of Minnesota, USA.
Eric H JensenDivision of Surgical Oncology, Department of Surgery, University of Minnesota, USA. Electronic address: Jense893@umn.edu.
University of Minnesota · US

Funding

Training the Next Generation of Surgeon-Scientists in PancreatologyT32DK108733 · NIDDK · UNIVERSITY OF MINNESOTA · PI Srinath Chinnakotla, MASATO YAMAMOTO · 2017 to 2026
$1.4M
NIDDK NIH HHS T32 DK108733
6 · The paper itself

Abstract

backgroundNodal positivity is a predictor of poor survival following resection for intrahepatic cholangiocarcinoma (ICC). The aim of this study was to evaluate the impact of surgical resection on survival in patients with lymph node (LN) positive ICC.

methodsAn augmented version of the Surveillance, Epidemiology, and End Results program database was utilized to identify patients with LN-positive ICC without distant metastases from 2000 to 2014. Patients were stratified by treatment: chemotherapy alone or surgical resection with/without chemotherapy. Survival was evaluated using Kaplan-Meier and Cox proportional hazard models.

results169 patients who underwent treatment for LN-positive ICC were identified. 88% underwent surgical resection and 12% underwent chemotherapy alone. The median survival for patients who underwent surgical resection was not different from patients treated with chemotherapy alone (19 months 95% Confidence Interval (CI) 17-33 versus 20 months CI 10-27, p = 0.323). A cox-proportional hazard ratio model demonstrated that black race was associated with worse survival (p < 0.05), while surgical resection was not independently associated with survival.

conclusionSurgical resection for patients with LN-positive ICC may not improve survival compared to chemotherapy alone. Pathologic LN evaluation should be performed prior to surgical resection, to improve patient selection and ensure receipt of optimal therapy.

Indexed as

Digestive System Surgical ProceduresAdolescentAdultAgedAntineoplastic AgentsBile Duct NeoplasmsBlack or African AmericanChemotherapy, AdjuvantCholangiocarcinomaClinical Decision-MakingDatabases, FactualFemaleHumansLymphatic MetastasisMaleMiddle AgedAntineoplastic Agents

Identifiers

PMID30274882
PMCPMC11966089
OpenAlexW2894157163

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.