Evidence map›Paper›PMID 30274412›Full record

ArticleTropical medicine and infectious disease2018

Development and Clinical Validation of a Multiplex Real-Time Quantitative PCR Assay for Human Infection by Anaplasma phagocytophilum and Ehrlichia chaffeensis.

Megan E Reller, J Stephen Dumler

Open access · goldAbstract read
In one paragraph

Article in Tropical medicine and infectious disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  3. Article
  4. Review
  5. Discovery and Surveillance of Tick-Borne Pathogens.Journal of medical entomology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Megan E RellerDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA. megan.reller@duke.edu.
J Stephen DumlerJoint Departments of Pathology, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Joint Pathology Center, Bethesda, MD 20814, USA. john.dumler@usuhs.edu.
Center for Global Health · USUniformed Services University of the Health Sciences · US

Funding

EHRLICHIA-GRANULOCYTE INTERACTIONS AND INFECTIONR01AI044102 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DUMLER, JOHN STEPHEN · 2000 to 2019
$5.3M
Virulence and Immunity of Granulocytic EhrlichiaeR01AI041213 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DUMLER, JOHN STEPHEN · 1996 to 2005
$1.3M
A. phagocytophilum and NF-kB signalingR21AI080911 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DUMLER, JOHN STEPHEN · 2009 to 2010
$451k
Reducing morbidity and mortality from acute febrile illness by improved diagnosisK23AI083931 · NIAID · JOHNS HOPKINS UNIVERSITY · PI RELLER, MEGAN ELIZABETH · 2010 to 2012
$407k
National Institute of Allergy and Infectious Diseases R01AI41213National Institute of Allergy and Infectious Diseases R01AI44102National Institute of Allergy and Infectious Diseases R21AI080911NIAID NIH HHS K23 AI083931NIAID NIH HHS R01 AI041213NIAID NIH HHS R01 AI044102NIAID NIH HHS R21 AI080911
6 · The paper itself

Abstract

backgroundHuman granulocytic anaplasmosis (HGA), caused by

methodsWe designed and clinically validated a multiplex real-time quantitative PCR assay for

resultsClinical sensitivity and specificity for

conclusionsThese assays could support early diagnosis and treatment as well as the high-throughput testing required for large epidemiologic studies.

Indexed as

Anaplasma phagocytophilumdiagnosticsEhrlichia chaffeensisetiology of fever studiesRickettsialesticks

Identifiers

PMID30274412
PMCPMC6136628
OpenAlexW2794121617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.