Evidence map›Paper›PMID 30274207›Full record

ReviewInternational journal of molecular sciences2018

The Main Determinants of Diabetes Mellitus Vascular Complications: Endothelial Dysfunction and Platelet Hyperaggregation.

Albino Carrizzo, Carmine Izzo, Marco Oliveti, Antonia Alfano, Nicola Virtuoso, Mario Capunzo, Paola Di Pietro, Mariaconsiglia Calabrese, Eros De Simone, Sebastiano Sciarretta and 6 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

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  14. Hyperglycemia and Venous Thromboembolism.Diagnostics (Basel, Switzerland) · 2024
    Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Albino CarrizzoIRCCS Neuromed, 86077 Pozzilli, IS, Italy. albino.carrizzo@gmail.com.
Carmine IzzoDepartement of Medicine and Surgery, University of Salerno, 84081 Baronissi, SA, Italy. carmine.izzo93@gmail.com.ORCID 0000-0001-8499-5428
Marco OlivetiDepartement of Medicine and Surgery, University of Salerno, 84081 Baronissi, SA, Italy. olivetimarco@yahoo.it.
Antonia AlfanoHeart Department, A.O.U. "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy. antonia.alfano@sangiovannieruggi.it.
Nicola VirtuosoDepartment of Cardiovascular Medicine, A.O.U. Federico II, 80131 Naples, Italy. n.virtuoso@hotmail.com.
Mario CapunzoDepartement of Medicine and Surgery, University of Salerno, 84081 Baronissi, SA, Italy. capunzom@virgilio.it.
Paola Di PietroDepartement of Medicine and Surgery, University of Salerno, 84081 Baronissi, SA, Italy. p.dipietro06@virgilio.it.
Mariaconsiglia CalabreseRehabilitation Department, A.O.U."San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy. mac.calabrese@virgilio.it.
Eros De SimoneHeart Department, A.O.U. "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy. eros.desimone@sangiovannieruggi.it.
Sebastiano SciarrettaIRCCS Neuromed, 86077 Pozzilli, IS, Italy. sebastianosciarretta@yahoo.it.
Giacomo FratiIRCCS Neuromed, 86077 Pozzilli, IS, Italy. fraticello@inwind.it.
Serena MigliarinoDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, 00161 Rome, Italy. smigliarino2018@virgilio.it.
Antonio DamatoIRCCS Neuromed, 86077 Pozzilli, IS, Italy. antonio.damato85@libero.it.
Mariateresa AmbrosioIRCCS Neuromed, 86077 Pozzilli, IS, Italy. mattyambr@gmail.com.
Francesco De CaroDepartement of Medicine and Surgery, University of Salerno, 84081 Baronissi, SA, Italy. fdecaro@unisa.it.ORCID 0000-0001-9659-9940
Carmine VecchioneIRCCS Neuromed, 86077 Pozzilli, IS, Italy. cvecchione@unisa.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus is a common disease that affects 3⁻5% of the general population in Italy. In some countries of northern Europe or in North America, it can even affect 6⁻8% of the population. Of great concern is that the number of cases of diabetes is constantly increasing, probably due to the increase in obesity and the sedentary nature of the population. According to the World Health Organization, in the year 2030 there will be 360 million people with diabetes, compared to 170 million in 2000. This has important repercussions on the lives of patients and their families, and on health systems that offer assistance to patients. In this review, we try to describe in an organized way the pathophysiological continuity between diabetes mellitus, endothelial dysfunction, and platelet hyperaggregation, highlighting the main molecular mechanisms involved and the interconnections.

Indexed as

AnimalsDiabetes MellitusEndothelium, VascularHumansModels, BiologicalPlatelet AggregationVascular Diseasesdiabetesendothelial dysfunctionmolecular mechanismsplatelets activation

Identifiers

PMID30274207
PMCPMC6212935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.