Evidence map›Paper›PMID 30274031›Full record

ArticleMaterials science & engineering. C, Materials for biological applications2018

Photostable, hydrophilic, and near infrared quaterrylene-based dyes for photoacoustic imaging.

Jaesok Yu, Shao Pin, Xiangwei Lin, Meng Su, Mingfeng Bai, Kang Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials science & engineering. C, Materials for biological applications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jaesok YuCenter for Ultrasound Molecular Imaging and Therapeutics, Department of Medicine & Heart and Vascular Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA 15213, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Shao PinDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Xiangwei LinCenter for Ultrasound Molecular Imaging and Therapeutics, Department of Medicine & Heart and Vascular Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA 15213, USA.
Meng SuVanderbilt University Institute of Imaging Sciences, Nashville, TN 37232, USA.
Mingfeng BaiDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA. Electronic address: mingfeng.bai@vumc.org.
Kang KimCenter for Ultrasound Molecular Imaging and Therapeutics, Department of Medicine & Heart and Vascular Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA 15213, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh and UPMC, Pittsburgh, PA 15219, USA. Electronic address: kangkim@upmc.edu.

Funding

A Novel Theranostic Platform for Targeted Cancer Therapy and Treatment MonitoringR21CA174541 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAI, MINGFENG · 2013 to 2015
$661k
NCI NIH HHS R21 CA174541
6 · The paper itself

Abstract

Novel near-infrared contrast agents based on the quaterrylene structure were strategically developed and tested for high photo-stability. Both a dendrimeric quaterrylene molecule, QR-G2-COOH, and a small molecule cationic quaterrylene dye, QR-4PyC4, remain optically stable and continue to generate a competitive photoacoustic response when irradiated by short near-infrared laser pulses for a relatively long time in an in-vitro cell study, unlike indocyanine green that rapidly decreases photoacoustic signal amplitude. The small molecule dye, QR-4PyC4 exhibits not only significantly higher cellular uptake rate than QR-G2-COOH and indocyanine green, but also low toxicity at a concentration of up to 10 μM. The dendrimeric dye, QR-G2-COOH that has surface functional groups available for conjugation with targeting and therapeutic agents shows the highest photoacoustic amplitude with high optical stability. Therefore, QR-4PyC4 can be a promising universal, sensitive and reliable photoacoustic contrast agent and QR-G2-COOH has great potential as a nano-platform with stable photoacoustic imaging capability.

Indexed as

Contrast MediaDendrimersFluorescent DyesInfrared RaysPhotoacoustic TechniquesCell Line, TumorHumansOptical ImagingContrast MediaDendrimersFluorescent DyesCellular uptakeHydrophilicNear infrared dyePhotoacousticsPhotostableQuaterrylene structure

Identifiers

PMID30274031
PMCPMC6172961

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.