Evidence map›Paper›PMID 30273979›Full record

ArticleInternational wound journal2019

Characterisation of impaired wound healing in a preclinical model of induced diabetes using wide-field imaging and conventional immunohistochemistry assays.

Mayer Saidian, Jonathan R T Lakey, Adrien Ponticorvo, Rebecca Rowland, Melissa Baldado, Joshua Williams, Maaikee Pronda, Michael Alexander, Antonio Flores, Li Shiri and 5 more

Erratum issuedOpen access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International wound journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Wound healing potential ofJournal of traditional and complementary medicine · 2023
    Article
  2. Dasatinib Ointment Promotes Healing of Murine Excisional Skin Wound.ACS pharmacology & translational science · 2023
    Article
  3. Article
  4. Article
  5. Use of human bone marrow mesenchymal stem cells immortalized by the expression of telomerase in wound healing in diabetic rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021
    Article
  6. IDE Degrades Nociceptin/Orphanin FQ through an Insulin Regulated Mechanism.International journal of molecular sciences · 2019
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Mayer SaidianThe Institute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID https://orcid.org/0000-0001-7511-4844
Jonathan R T LakeyDepartment of Surgery, University of California Irvine, Orange, California.
Adrien PonticorvoBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California.
Rebecca RowlandBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California.
Melissa BaldadoBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California.
Joshua WilliamsBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California.
Maaikee ProndaBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California.
Michael AlexanderDepartment of Surgery, University of California Irvine, Orange, California.
Antonio FloresDepartment of Surgery, University of California Irvine, Orange, California.
Li ShiriDepartment of Surgery, University of California Irvine, Orange, California.
Stellar ZhangDepartment of Surgery, University of California Irvine, Orange, California.
Bernard ChoiBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California.
Roni KohenThe Institute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel.
Bruce J TrombergBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California.
Anthony J DurkinBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California.
University of California, Irvine · USHebrew University of Jerusalem · IL

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI BOTVINICK, ELLIOT LAWRENCE · 2012 to 2017
$7.0M
Air Force Office of Scientific Research FA9550-14-1-0034Air Force Office of Scientific Research FA9550-17-1-0193CSR NIH HHS NIBIB P41EB015890NCATS NIH HHS UL1 TR001414NIBIB NIH HHS P41 EB015890
6 · The paper itself

Abstract

Major complications of diabetes lead to inflammation and oxidative stress, delayed wound healing, and persistent ulcers. The high morbidity, mortality rate, and associated costs of management suggest a need for non-invasive methods that will enable the early detection of at-risk tissue. We have compared the wound-healing process that occurs in streptozotocin (STZ)-treated diabetic rats with non-diabetic controls using contrast changes in colour photography (ie, Weber Contrast) and the non-invasive optical method Spatial Frequency Domain Imaging (SFDI). This technology can be used to quantify the structural and metabolic properties of in-vivo tissue by measuring oxyhaemoglobin concentration (HbO

Indexed as

AnimalsDiabetes Mellitus, ExperimentalImmunohistochemistryLaser-Doppler FlowmetryMaleRatsStreptozocinWound HealingWounds and InjuriesStreptozocindiabeteshaemodynamicsinflammationspatial frequency domain imagingwound healing

Identifiers

PMID30273979
PMCPMC6329645
OpenAlexW2894764917

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.