ArticleiScience2018
Bioinspired Anti-digestive Hydrogels Selected by a Simulated Gut Microfluidic Chip for Closing Gastrointestinal Fistula.
Article in iScience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 41 citations in OpenAlex.
- Mechanically Active Hydrogel for Healing Intestinal Fistulas through the YAP-Mediated Mechanosensitization of Intestinal Epithelial Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Microfluidic intestinal organoid-on-a-chip uncovers therapeutic targets by recapitulating oxygen dynamics of intestinal IR injury.Bioactive materials · 2023Article
- Bioinspired Hydrogels as Platforms for Life-Science Applications: Challenges and Opportunities.Polymers · 2022Review
- Tissue engineering of the gastrointestinal tract: the historic path to translation.Journal of biological engineering · 2022Review
- Recent Development of Drug Delivery Systems through Microfluidics: From Synthesis to Evaluation.Pharmaceutics · 2022Review
- Bioinstructive Layer-by-Layer-Coated Customizable 3D Printed Perfusable Microchannels Embedded in Photocrosslinkable Hydrogels for Vascular Tissue Engineering.Biomolecules · 2021Article
- A polypropylene mesh coated with interpenetrating double network hydrogel for local drug delivery in temporary closure of open abdomen.RSC advances · 2020Article
- Technique Advances in Enteroatmospheric Fistula Isolation After Open Abdomen: A Review and Outlook.Frontiers in surgery · 2020Review
- Sandwich-structure hydrogels implement on-demand release of multiple therapeutic drugs for infected wounds.RSC advances · 2019Article
- Hybrid material for open abdomen: saving the wound from intestinal fistula.Journal of materials science. Materials in medicine · 2019Article
- Application of a 3D-printed "fistula stent" in plugging enteroatmospheric fistula with open abdomen: A case report.World journal of gastroenterology · 2019Article
- Gut bioengineering promotes gut repair and pharmaceutical research: a review.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anti-digestive features given to hydrogels can prolong their action time in gut environment; however, these types of hydrogels have rarely been reported. Inspired by indigestibility of dietary fibers, we introduced an injectable covalent hydrogel through photopolymerization of glycidyl methacrylate-modified xanthan. This newly synthesized hydrogel exhibited a specific concentration-dependent porosity, swelling ratio, and stiffness. The intestinal epithelial cells-6 could grow on the surface of the stiffer hydrogel, and achieved their gut barrier functions. A simulated gut microfluidic chip was manufactured to demonstrate the hydrogel's good performance of anti-digestion compared with the current product, fibrin sealant. Furthermore, calcium ions could induce the swelling-shrinking behavior of the hydrogel, which assisted in removing the hydrogels at the proper time so as to avoid the mismatch of hydrogel degradation and tissue regeneration. Therefore, this hydrogel is expected to be an outstanding gut repair material, especially for closing gastrointestinal fistula.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.