ReviewEcotoxicology and environmental safety2018
Current approaches for safer design of engineered nanomaterials.
Review in Ecotoxicology and environmental safety, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 38 citations in OpenAlex.
- Targeted Drug Delivery Strategies in Overcoming Antimicrobial Resistance: Advances and Future Directions.Pharmaceutics · 2025Review
- Review
- Diverse Pathways of Engineered Nanoparticle-Induced NLRP3 Inflammasome Activation.Nanomaterials (Basel, Switzerland) · 2022Review
- Toxicity of metal-based nanoparticles: Challenges in the nano era.Frontiers in bioengineering and biotechnology · 2022Review
- The Role of Apoptosis Pathway in the Cytotoxicity Induced by Fresh and Aged Zinc Oxide Nanoparticles.Nanoscale research letters · 2021Article
- ZnO nanoparticles for photodegradation of humic acid in water.Environmental science and pollution research international · 2021Article
- Nanoparticle-Based Activatable Probes for Bioimaging.Advanced biology · 2021Review
- Safe Nanoparticles: Are We There Yet?International journal of molecular sciences · 2020Review
- Iron-Doping of Copper Oxide Nanoparticles Lowers Their Toxic Potential on C6 Glioma Cells.Neurochemical research · 2020Article
- Molecular and Cellular Risk Assessment of Healthy Human Cells and Cancer Human Cells Exposed to Nanoparticles.International journal of molecular sciences · 2019Article
- Carbonaceous Nanomaterials for Phototherapy of Cancer.Technology in cancer research & treatmentReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The surge of applications for engineered nanomaterials (ENMs) across multiple industries raises safety concerns regarding human health and environmental impacts. ENMs can be hazardous through various mechanisms, including, particle dissolution and shedding of toxic metal ions, surface reactivity and perturbation of cellular membranes, lysosomal membrane damage, activation of inflammation pathways (e.g., NLRP3 inflammasome), etc. The aim of this review is therefore to discuss practical approaches for the safer design of ENMs through modification of their physicochemical properties that can lead to acute and/or chronic toxicity. This is premised on our understanding of how different ENMs induce toxicity within various biological systems. We will summarize studies that have investigated nanomaterial toxicity both in vitro and in vivo to understand the underlying mechanisms by which nanoparticles can cause inflammation, fibrosis, and cell death. With this knowledge, researchers have identified several design strategies to counter these mechanisms of toxicity. In particular, we will discuss how metal doping, surface coating and covalent functionalization, and adjustment of surface oxidation state and aspect ratio of ENMs could reduce their potential adverse effects. While these strategies might be effective under certain experimental and exposure scenarios, more research is required to fully apply this knowledge in real life applications of nanomaterials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.