Evidence map›Paper›PMID 30273797›Full record

ArticlePsychoneuroendocrinology2019

Amygdalar activity predicts future incident diabetes independently of adiposity.

Michael T Osborne, Amorina Ishai, Basma Hammad, Brian Tung, Ying Wang, Amos Baruch, Zahi A Fayad, Jon T Giles, Janet Lo, Lisa M Shin and 4 more

Open access · greenAbstract read
In one paragraph

Article in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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  12. Heart-brain axis: Pushing the boundaries of cardiovascular molecular imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Michael T OsborneCardiac MR-PET-CT Program, Massachusetts General Hospital, 165 Cambridge St, Suite 400, Boston, MA, 02114, USA; Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, MA, 02114, USA. Electronic address: mosborne@mgh.harvard.edu.
Amorina IshaiCardiac MR-PET-CT Program, Massachusetts General Hospital, 165 Cambridge St, Suite 400, Boston, MA, 02114, USA. Electronic address: amorinaishai@gmail.com.
Basma HammadCardiac MR-PET-CT Program, Massachusetts General Hospital, 165 Cambridge St, Suite 400, Boston, MA, 02114, USA. Electronic address: basmaabdelkader@gmail.com.
Brian TungCardiac MR-PET-CT Program, Massachusetts General Hospital, 165 Cambridge St, Suite 400, Boston, MA, 02114, USA. Electronic address: btung@nymc.edu.
Ying WangCardiac MR-PET-CT Program, Massachusetts General Hospital, 165 Cambridge St, Suite 400, Boston, MA, 02114, USA. Electronic address: ywang88@mgh.harvard.edu.
Amos BaruchOMNI Biomarker Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. Electronic address: baruch.amos@gene.com.
Zahi A FayadTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, 10029, USA. Electronic address: zahi.fayad@mssm.edu.
Jon T GilesDepartment of Rheumatology, Columbia University, 630 W. 168th St, New York, NY, 10032, USA. Electronic address: jtg2122@cumc.columbia.edu.
Janet LoNeuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA. Electronic address: jlo@mgh.harvard.edu.
Lisa M ShinDepartment of Psychology, Tufts University, 490 Boston Ave, Medford, MA, 02155, USA; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Charlestown, MA, 02129, USA. Electronic address: Lisa.Shin@tufts.edu.
Steven K GrinspoonNeuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA; Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA. Electronic address: sgrinspoon@mgh.harvard.edu.
Karestan C KoenenHarvard University T.H. Chan School of Public Health, 677 Huntington Ave, Kresge Building, Boston, MA, 02115, USA. Electronic address: kkoenen@hsph.harvard.edu.
Roger K PitmanDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Charlestown, MA, 02129, USA. Electronic address: roger.pitman@mgh.harvard.edu.
Ahmed TawakolCardiac MR-PET-CT Program, Massachusetts General Hospital, 165 Cambridge St, Suite 400, Boston, MA, 02114, USA; Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, MA, 02114, USA. Electronic address: atawakol@mgh.harvard.edu.
Massachusetts General Hospital · USHarvard University · USColumbia University Irving Medical Center · USGene Therapy Laboratory · FRIcahn School of Medicine at Mount Sinai · USTufts University · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Translational imaging and nanomedicine in inflammatory atherosclerosisP01HL131478 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Philip Martyn Robson · 2017 to 2026
$24.3M
MR/PET Imaging of coronary atherosclerosisR01HL071021 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FAYAD, ZAHI A. · 2002 to 2019
$7.8M
Cardiac MR and CT ResearchT32HL076136 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEILAN, TOMAS G · 2004 to 2019
$4.9M
Novel PET/CT and Treatment Strategies to reduce PTS following DVTR01HL137913 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI JAFFER, FAROUC AMIN, TAWAKOL, AHMED A · 2017 to 2020
$3.3M
Effect of Low Dose Methotrexate on Arterial Inflammation in HIVR01HL122177 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI TAWAKOL, AHMED A · 2014 to 2017
$1.2M
Cardiovascular Imaging in Ischemic Heart DiseaseK24HL113128 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HOFFMANN, UDO · 2012 to 2020
$1.1M
Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study)R61HL141047 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOFFMANN, UDO, HSUE, PRISCILLA Y. · 2018 to 2018
$730k
NHLBI NIH HHS K24 HL113128NHLBI NIH HHS P01 HL131478NHLBI NIH HHS R01 HL071021NHLBI NIH HHS R01 HL122177NHLBI NIH HHS R01 HL137913NHLBI NIH HHS R61 HL141047NHLBI NIH HHS T32 HL076136NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

While it is established that psychosocial stress increases the risk of developing diabetes mellitus (DM), two key knowledge gaps remain: 1) the neurobiological mechanisms that are involved in mediating that risk, and 2) the role, if any, that adiposity plays in that mechanism. We tested the hypotheses that: 1) metabolic activity in the amygdala (AmygA), a key center involved in the neurobiological response to stress, associates with subsequent DM risk, and 2) this association is independent of adiposity. AmygA and adipose tissue volumes were measured, and serial blood assessments for DM were obtained in 232 subjects who underwent combined

Indexed as

AdiposityAdultAgedAmygdalaBiomarkersCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleFluorodeoxyglucose F18HumansIncidenceLongitudinal StudiesMaleMiddle AgedObesityPositron Emission Tomography Computed TomographyBiomarkersFluorodeoxyglucose F18AmygdalaDiabetes mellitusPositron emission tomography/computed tomographyVisceral adiposity

Identifiers

PMID30273797
PMCPMC6398601
OpenAlexW2892549225

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.