ArticlePsychiatry research. Neuroimaging2018
White matter microstructural correlates of relapse in alcohol dependence.
Article in Psychiatry research. Neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- White matter microstructure alterations from alcohol use disorder persist into early abstinence.Brain communications · 2026Article
- Connectomics modeling of regional networks of white-matter fractional anisotropy to predict the severity of young adult drinking.Quantitative imaging in medicine and surgery · 2025Article
- White matter microstructural alterations are associated with cognitive decline in benzodiazepine use disorders: a multi-shell diffusion magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2025Article
- White Matter Differences in Early-Stage Alcohol Use Disorder: Diffusion Tensor and Neurite Orientation Dispersion and Density Measures of Structural Integrity.Addiction biology · 2025Article
- Alcohol-Induced Changes in Brain Microstructure: Uncovering Novel Pathophysiological Mechanisms of AUD Using Translational DTI in Humans and Rodents.Current topics in behavioral neurosciences · 2025Review
- Imaging neuroinflammation in individuals with substance use disorders.The Journal of clinical investigation · 2024Review
- Changes in processing speed during early abstinence from alcohol dependence.Journal of psychopharmacology (Oxford, England) · 2024Article
- Relating white matter microstructure in theoretically defined addiction networks to relapse in alcohol use disorder.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Alcohol use disorder-associated structural and functional characteristics of the insula.Journal of neuroscience research · 2022Article
- Alcohol and the Brain.Nutrients · 2021Review
- Microstructural damage of white-matter tracts connecting large-scale networks is related to impaired executive profile in alcohol use disorder.NeuroImage. Clinical · 2020Article
- Does an Over-Connected Visual Cortex Undermine Efforts to Stay Sober After Treatment for Alcohol Use Disorder?Frontiers in psychiatry · 2020Article
- Peripheral Acid Sphingomyelinase Activity Is Associated with Biomarkers and Phenotypes of Alcohol Use and Dependence in Patients and Healthy Controls.International journal of molecular sciences · 2018Article
- Enhancing treatment outcomes of Alcohol Use Disorder patients through ICT-based cognitive training tools: a randomized controlled trial.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Identification of neural correlates of relapse to alcohol after treatment is clinically important as it may inform better substance abuse treatment. Few studies have specifically analyzed the white matter microstructure in treatment seekers as it might relate to relapse risk versus long-term abstinence. Using 4 Tesla diffusion tensor imaging, we compared two groups of one-month-abstinent treatment-seekers, who were classified based on their drinking status between six and nine months after treatment initiation. We hypothesized that subsequent relapsers had greater white matter microstructural deficits in specific brain regions than long-term abstainers. At one month of abstinence, 37 future relapsers versus 25 future abstainers had lower fractional anisotropy (a measure of axonal organization and membrane integrity) in the corpus callosum and right stria terminalis/fornix, higher diffusivity in the genu of the corpus callosum, left and right stria terminalis/fornix, and lower diffusivity in left anterior corona radiata. These differences existed despite similar lifetime and recent drinking and smoking histories in the groups. Longer smoking duration in relapsers was associated with lower fractional anisotropy in right stria terminalis/fornix. The study identified specific microstructural biomarkers of alcohol relapse risk in adults, contributing to the definition of a neurobiological relapse risk profile in alcohol use disorder.
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