Evidence map›Paper›PMID 30273448›Full record

Trial reportHuman brain mapping2019

Focal application of accelerated iTBS results in global changes in graph measures.

Deborah C W Klooster, Suzanne L Franklin, René M H Besseling, Jaap F A Jansen, Karen Caeyenberghs, Romain Duprat, Albert P Aldenkamp, Anton J A de Louw, Paul A J M Boon, Chris Baeken

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Deborah C W KloosterDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.ORCID 0000-0002-9850-9192
Suzanne L FranklinDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
René M H BesselingDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Jaap F A JansenDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Karen CaeyenberghsAustralian Catholic University, Melbourne, Australia.
Romain DupratDepartment of Neurology, Ghent University Hospital, Ghent, Belgium.
Albert P AldenkampDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Anton J A de LouwDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Paul A J M BoonDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Chris BaekenUniversity Hospital Brussels, Jette, Belgium.ORCID 0000-0001-9885-3041

Funding

Ghent University Multidisciplinary Research Partnership
6 · The paper itself

Abstract

Graph analysis was used to study the effects of accelerated intermittent theta burst stimulation (aiTBS) on the brain's network topology in medication-resistant depressed patients. Anatomical and resting-state functional MRI (rs-fMRI) was recorded at baseline and after sham and verum stimulation. Depression severity was assessed using the Hamilton Depression Rating Scale (HDRS). Using various graph measures, the different effects of sham and verum aiTBS were calculated. It was also investigated whether changes in graph measures were correlated to clinical responses. Furthermore, by correlating baseline graph measures with the changes in HDRS in terms of percentage, the potential of graph measures as biomarker was studied. Although no differences were observed between the effects of verum and sham stimulation on whole-brain graph measures and changes in graph measures did not correlate with clinical response, the baseline values of clustering coefficient and global efficiency showed to be predictive of the clinical response to verum aiTBS. Nodal effects were found throughout the whole brain. The distribution of these effects could not be linked to the strength of the functional connectivity between the stimulation site and the node. This study showed that the effects of aiTBS on graph measures distribute beyond the actual stimulation site. However, additional research into the complex interactions between different areas in the brain is necessary to understand the effects of aiTBS in more detail.

Indexed as

ConnectomeAdultCross-Over StudiesDepressive Disorder, Treatment-ResistantDouble-Blind MethodEvoked Potentials, MotorHumansMagnetic Resonance ImagingNerve NetNeuronavigationPlacebosSeverity of Illness IndexTheta RhythmTranscranial Magnetic StimulationPlacebosaccelerated intermittent theta burst stimulationfunctional connectivitygraph analysistranscranial magnetic stimulation

Identifiers

PMID30273448
PMCPMC6585849

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.