ArticlePLoS computational biology2018
Cooperation of dual modes of cell motility promotes epithelial stress relaxation to accelerate wound healing.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 68 citations in OpenAlex.
- Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis.Current biology : CB · 2026Article
- Physical models of embryonic epithelial healing.PLoS computational biology · 2026Review
- Epidermal stem cells control periderm injury repair via matrix-driven specialization of intercellular junctions.Nature communications · 2025Article
- Modeling the roles of cohesotaxis, cell-intercalation, and tissue geometry in collective cell migration of Xenopus mesendoderm.Biology open · 2024Article
- Confinement induces internal flows in adherent cell aggregates.Journal of the Royal Society, Interface · 2024Article
- Effect of non-linear strain stiffening in eDAH and unjamming.Soft matter · 2024Article
- Lamellipodia dynamics and microrheology in endothelial cell paracellular gap closure.Biophysical journal · 2023Article
- Free and Interfacial Boundaries in Individual-Based Models of Multicellular Biological systems.Bulletin of mathematical biology · 2023Article
- A mathematical model of calcium signals around laser-induced epithelial wounds.Molecular biology of the cell · 2023Article
- Micro and Macroscopic Stress-Strain Relations in Disordered Tessellated Networks.Physical review letters · 2023Article
- Mechanosensory feedback loops during chronic inflammation.Frontiers in cell and developmental biology · 2023Review
- Interplay between substrate rigidity and tissue fluidity regulates cell monolayer spreading.Soft matter · 2022Article
- [Research advances on the biomechanical micro- environment facilitated wound repair through the regulation of cell migration].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Review
- Mathematical Model Predicts that Acceleration of Diabetic Wound Healing is Dependent on Spatial Distribution of VEGF-A mRNA (AZD8601).Cellular and molecular bioengineering · 2021Article
- Robustness of epithelial sealing is an emerging property of local ERK feedback driven by cell elimination.Developmental cell · 2021Article
- Hindbrain neuropore tissue geometry determines asymmetric cell-mediated closure dynamics in mouse embryos.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion.Nature communications · 2021Article
- Junctional and cytoplasmic contributions in wound healing.Journal of the Royal Society, Interface · 2020Article
- Effect of Geometric Curvature on Collective Cell Migration in Tortuous Microchannel Devices.Micromachines · 2020Article
- Polarity during tissue repair, a multiscale problem.Current opinion in cell biology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Collective cell migration in cohesive units is vital for tissue morphogenesis, wound repair, and immune response. While the fundamental driving forces for collective cell motion stem from contractile and protrusive activities of individual cells, it remains unknown how their balance is optimized to maintain tissue cohesiveness and the fluidity for motion. Here we present a cell-based computational model for collective cell migration during wound healing that incorporates mechanochemical coupling of cell motion and adhesion kinetics with stochastic transformation of active motility forces. We show that a balance of protrusive motility and actomyosin contractility is optimized for accelerating the rate of wound repair, which is robust to variations in cell and substrate mechanical properties. This balance underlies rapid collective cell motion during wound healing, resulting from a tradeoff between tension mediated collective cell guidance and active stress relaxation in the tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.