ArticlePLoS genetics2018
Amn1 governs post-mitotic cell separation in Saccharomyces cerevisiae.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Pervasive weak incompatibilities shape phenotypic variation and genome evolution in yeast hybrids.Nature communications · 2026Article
- Constraints on the G1/S transition pathway may favor selection of multicellularity as a passenger phenotype.eLife · 2026Article
- Directed evolution for cell separation in natural isolates of budding yeast reveals selection to deactivate AMN1 and the Rim101 pathway in haploids and selection in favor of Hawthorne's deletion in diploids.G3 (Bethesda, Md.) · 2026Article
- Evaluation of cultivation performance of S. cerevisiae strains expressing GLP-1-GIP peptide precursors.Biotechnology letters · 2026Article
- Weak pervasive incompatibilities and compensatory adaptation drive hybrid genome evolution in yeast.bioRxiv : the preprint server for biology · 2026Article
- Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast.microPublication biology · 2026Article
- Discordant effects of maternal age on the human MII oocyte transcriptome.Molecular human reproduction · 2025Article
- Eliminating viscosity challenges in continuous cultivation of yeast producing a GLP-1 like peptide.Microbial cell factories · 2025Article
- Alternating selection for dispersal and multicellularity favors regulated life cycles.Current biology : CB · 2023Article
- Strain-dependent differences in coordination of yeast signalling networks.The FEBS journal · 2023Article
- Complex genetics cause and constrain fungal persistence in different parts of the mammalian body.Genetics · 2022Article
- Drug-dependent growth curve reshaping reveals mechanisms of antifungal resistance in Saccharomyces cerevisiae.Communications biology · 2022Article
- The Cbk1-Ace2 axis guides Candida albicans from yeast to hyphae and back again.Current genetics · 2021Article
- Genome Duplication Increases Meiotic Recombination Frequency: A Saccharomyces cerevisiae Model.Molecular biology and evolution · 2021Article
- Article
- Roles of Elm1 in antifungal susceptibility and virulence in Candida glabrata.Scientific reports · 2020Article
- Disadvantages and benefits of evolved unicellularity versus multicellularity in budding yeast.Ecology and evolution · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
Post-mitotic cell separation is one of the most prominent events in the life cycle of eukaryotic cells, but the molecular underpinning of this fundamental biological process is far from being concluded and fully characterized. We use budding yeast Saccharomyces cerevisiae as a model and demonstrate AMN1 as a major gene underlying post-mitotic cell separation in a natural yeast strain, YL1C. Specifically, we define a novel 11-residue domain by which Amn1 binds to Ace2. Moreover, we demonstrate that Amn1 induces proteolysis of Ace2 through the ubiquitin proteasome system and in turn, down-regulates Ace2's downstream target genes involved in hydrolysis of the primary septum, thus leading to inhibition of cell separation and clumping of haploid yeast cells. Using ChIP assays and site-specific mutation experiments, we show that Ste12 and the a1-α12 heterodimer are two direct regulators of AMN1. Specifically, a1-α2, a diploid-specific heterodimer, prevents Ste12 from inactivating AMN1 through binding to its promoter. This demonstrates how the Amn1-governed cell separation is highly cell type dependent. Finally, we show that AMN1368D from YL1C is a dominant allele in most strains of S. cerevisiae and evolutionarily conserved in both genic structure and phenotypic effect in two closely related yeast species, K. lactis and C. glabrata.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.