Evidence map›Paper›PMID 30273231›Full record

Observational studyAnesthesia and analgesia2019

Clock Drawing Performance Slows for Older Adults After Total Knee Replacement Surgery.

Loren P Hizel, Eric D Warner, Margaret E Wiggins, Jared J Tanner, Hari Parvataneni, Randall Davis, Dana L Penney, David J Libon, Patrick Tighe, Cynthia W Garvan and 1 more

Abstract readObservational Study
In one paragraph

Observational study in Anesthesia and analgesia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Review
  5. The New Frontier of Perioperative Cognitive Medicine for Alzheimer's Disease and Related Dementias.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Phenotyping Cognitive Impairment using Graphomotor and Latency Features in Digital Clock Drawing Test.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2020
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Loren P HizelFrom the Clinical and Health Psychology, University of Florida, Gainesville, Florida.
Eric D WarnerFrom the Clinical and Health Psychology, University of Florida, Gainesville, Florida.
Margaret E WigginsFrom the Clinical and Health Psychology, University of Florida, Gainesville, Florida.
Jared J TannerFrom the Clinical and Health Psychology, University of Florida, Gainesville, Florida.
Hari ParvataneniDepartment of Orthopedic Surgery, University of Florida College of Medicine, Gainesville, Florida.
Randall DavisComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Boston, Massachusetts.
Dana L PenneyDepartment of Neurology, Lahey Clinic, Boston, Massachusetts.
David J LibonDepartments of Geriatric and Gerontology.
Patrick TigheDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida.
Cynthia W GarvanDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida.
Catherine C PriceFrom the Clinical and Health Psychology, University of Florida, Gainesville, Florida.

Funding

University of Florida - Mt. Sinai Medical Center AD Research CenterP50AG047266 · NIA · UNIVERSITY OF FLORIDA · PI FEBO, MARCELO · 2015 to 2019
$7.3M
Research Training in Non-Pharmacological Interventions for Cognition in Aging, MCI, and Alzheimer's DiseaseT32AG020499 · NIA · UNIVERSITY OF FLORIDA · PI MARSISKE, MICHAEL, SMITH, GLENN E. · 2003 to 2024
$3.7M
PRECEDE: PREsurgical Cognitive Evaluation via Digital clockfacEdrawingR01AG055337 · NIA · UNIVERSITY OF FLORIDA · PI CATHERINE E PRICE, Parisa Rashidi · 2017 to 2026
$3.2M
Neuroimaging Biomarkers for Post-Operative Cognitive Decline in Older AdultsR01NR014181 · NINR · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2012 to 2016
$2.3M
NIA NIH HHS P50 AG047266NIA NIH HHS R01 AG055337NIA NIH HHS T32 AG020499NINR NIH HHS R01 NR014181
6 · The paper itself

Abstract

backgroundClock drawing is a neurocognitive screening tool used in preoperative settings. This study examined hypothesized changes in clock drawing to command and copy test conditions 3 weeks and 3 months after total knee arthroplasty (TKA) with general anesthesia.

methodsParticipants included 67 surgery and 66 nonsurgery individuals >60 years who completed the digital clock drawing test before TKA (or a pseudosurgery date), and 3 weeks and 3 months postsurgery. Generalized linear mixed models assessed digital clock drawing test latency (ie, total time to completion, seconds between digit placement) and graphomotor output (ie, total number of strokes, clock size). Reliable change analyses examined the percent of participants showing change beyond differences found in nonsurgery peers.

resultsAfter adjusting for age, education, and baseline cognition, both digital clock drawing test latency measures were significantly different for surgery and nonsurgery groups, where the surgery group performed slower on both command and copy test conditions. Reliable change analyses 3 weeks after surgery found that total time to completion was slower among 25% of command and 21% of copy constructions in the surgery group. At 3 months, 18% of surgery participants were slower than nonsurgery peers. Neither graphomotor measure significantly changed over time.

conclusionsClock drawing construction slowed for nearly one-quarter of patients after TKA surgery, whereas nonsurgery peers showed the expected practice effect, ie, speed increased from baseline to follow-up time points. Future research should investigate the neurobiological basis for these changes after TKA.

Indexed as

CognitionNeuropsychological TestsAgedArthroplasty, Replacement, KneeFemaleHumansMaleMiddle AgedPostoperative Cognitive ComplicationsPredictive Value of TestsProspective StudiesReaction TimeReproducibility of ResultsRisk FactorsTime FactorsTreatment Outcome

Identifiers

PMID30273231
PMCPMC6579692

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.