ArticleHuman brain mapping2018
Disrupted interactions among the hippocampal, dorsal attention, and central-executive networks in amnestic mild cognitive impairment.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An Activation Likelihood Estimation Meta-Analysis of Specific Functional Alterations in Dorsal Attention Network in Mild Cognitive Impairment.Frontiers in neuroscience · 2022Pooled it
- Multi-networks connectivity at baseline predicts the clinical efficacy of left angular gyrus-navigated rTMS in the spectrum of Alzheimer's disease: A sham-controlled study.CNS neuroscience & therapeutics · 2023Trial
- Brain functional connectivity network alterations in occupational aluminum exposure among workers with mild cognitive impairment.Scientific reports · 2026Article
- Disrupted Brain Hierarchical Organization in Alzheimer's Disease Progression.medRxiv : the preprint server for health sciences · 2025Article
- Multivariate whole brain neurodegenerative-cognitive-clinical severity mapping in the Alzheimer's disease continuum using explainable AI.medRxiv : the preprint server for health sciences · 2025Article
- Characterizing multivariate regional hubs for schizophrenia classification, sex differences, and brain age estimation using explainable AI.medRxiv : the preprint server for health sciences · 2025Article
- An explainable AI approach for mapping multivariate regional brain age and clinical severity patterns in Alzheimer's disease.Biology methods & protocols · 2025Article
- Dysregulated Salience Network Control over Default-Mode and Central-Executive Networks in Schizophrenia Revealed Using Stochastic Dynamical Causal Modeling.Brain connectivity · 2024Article
- Repetitive transcranial magnetic stimulation regulates effective connectivity patterns of brain networks in the spectrum of preclinical Alzheimer's disease.Frontiers in aging neuroscience · 2024Article
- Predicting cognitive dysfunction and regional hubs using Braak staging amyloid-beta biomarkers and machine learning.Brain informatics · 2023Article
- Temporal Irreversibility of Large-Scale Brain Dynamics in Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Multi-feature computational framework for combined signatures of dementia in underrepresented settings.Journal of neural engineering · 2022Article
- Abnormal Dynamic Functional Networks in Subjective Cognitive Decline and Alzheimer's Disease.Frontiers in computational neuroscience · 2022Article
- Verbal Learning and Longitudinal Hippocampal Network Connectivity in Temporal Lobe Epilepsy Surgery.Frontiers in neurology · 2022Article
- Effects of ApoE genotype on clinical phenotypes in early-onset and late-onset Alzheimer's disease in China: Data from the PUMCH dementia cohort.Brain and behavior · 2021Article
- Neuroimaging mechanisms of high-frequency repetitive transcranial magnetic stimulation for treatment of amnestic mild cognitive impairment: a double-blind randomized sham-controlled trial.Neural regeneration research · 2021Article
- Self-reference Network-Related Interactions During the Process of Cognitive Impairment in the Early Stages of Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
- Estimating regional cerebral blood flow using resting-state functional MRI via machine learning.Journal of neuroscience methods · 2020Article
- Disrupted interactions among the hippocampal, dorsal attention, and central-executive networks in amnestic mild cognitive impairment.Human brain mapping · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Neuroimaging investigations consistently demonstrate that the neural processes involve complex interactions between the large-scale networks. Among those networks, the dorsal attention network (DAN) and the central-executive network (CEN) have been previously shown to exhibit anti-correlated activity with the default-mode network (DMN) in cognitively normal people. In amnestic mild cognitive impairment (MCI) and Alzheimer's disease, the hippocampal network (HCN)-a key memory processing system-and its interactions with other networks have gathered central interest. The current study aims to evaluate the patterns of functional architectures of the HCN with the three networks-DAN, CEN, and DMN-in amnestic MCI and normal controls (NC) to test the hypothesis that the interactions of HCN with other networks alter in MCI. We recorded the resting state functional MRI, assessed patterns of functional architectures between the four networks using dynamical causal modeling, and compared between NC and MCI. Our analysis showed that the DAN modulates the activity between the HCN and the DMN in both MCI and NC. We further uncovered that the DAN modulates the activity between the HCN and the CEN in NC, but such modulation is impaired in MCI. We found an association between impaired modulation and Montreal cognitive assessment (R = 0.349). Overall, our findings provide important insight in understanding the neuroimaging signature of amnestic MCI and/or Alzheimer's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.