ReviewThe Journal of clinical investigation2018
Regulatory T cells in embryo implantation and the immune response to pregnancy.
Review in The Journal of clinical investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06281262 (The Role of Selected Immunological Indicators and Microbiota in Patients Experiencing Premature Birth and Preeclampsia), which is not on this map. Cited by 240 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Selected Immunological Indicators and Microbiota in Patients Experiencing Premature Birth and Preeclampsia
Who cites it
240 citing papers in PubMed, 5 syntheses or guidelines pooled it, 432 citations in OpenAlex.
- Global research trends and future frontiers in the immunology of spontaneous abortion: a 25-year scientometric analysis.Frontiers in immunology · 2026Pooled it
- Association of IL-17 and IL-27 polymorphisms with susceptibility to recurrent pregnancy loss and pre-eclampsia: A systematic review and meta-analysis.Immunity, inflammation and disease · 2023Pooled it
- Regulatory T cells in the peripheral blood of women with gestational diabetes: a systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- The effectiveness of immunomodulatory therapies for patients with repeated implantation failure: a systematic review and network meta-analysis.Scientific reports · 2022Pooled it
- Global transcriptomic changes occur in uterine fluid-derived extracellular vesicles during the endometrial window for embryo implantation.Human reproduction (Oxford, England) · 2021Pooled it
- Rethinking the origins and functions of adaptive immunity.Trends in immunology · 2026Review
- Alterations in Vaginal Microbiota Associated with Pregnancy Outcomes in Dairy Cows Revealed by 16S rRNA Gene Sequencing.Microorganisms · 2026Article
- Association between triglyceride glucose index and spontaneous preterm birth: Evidence from a retrospective cohort study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Deep immune profiling of endometrial and peripheral blood cells in endometriosis.Human reproduction (Oxford, England) · 2026Observational
- FUBP1 lactylation suppresses trophoblast function in fetal growth restriction.Clinical epigenetics · 2026Article
- Short-Chain Fatty Acids May Promote Regulatory T Cell Induction to Enhance Maternal Immune Tolerance in Early Pregnancy.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Double negative T cells decline in inflammatory reproductive dysfunction.Scientific reports · 2026Article
- SERPINA3 and NDRG1 are critical diagnostic immune genes associated with macrophages in preeclampsia.Scientific reports · 2026Article
- Association of HDL-cholesterol related inflammatory ratios with reproductive outcomes in women with polycystic ovary syndrome undergoing frozen-thawed embryo transfer.Journal of ovarian research · 2026Article
- Inverse association between peripheral natural killer cells and thyroid autoimmunity in cases of miscarriage: Evidence from a cross-sectional study.The Journal of international medical research · 2026Article
- The Role of Immunologic Factors in Endometrial Receptivity: An Embryo-Endometrium Dialogue.International journal of molecular sciences · 2026Review
- Association of cured chronic endometritis after antibiotic treatment with outcomes of the subsequent frozen-thawed embryo transfer cycle among women with first implantation failure: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Endometrial Epithelial Lactate Deficiency Drives CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Innate Immunity and Microbial Recognition in Reproduction: From Barrier Defense to Maternal-Fetal Tolerance.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Inflammation at the Maternal-Fetal Interface: Mechanisms Linking Maternal-Fetal Immunity to Preeclampsia and Fetal Growth Restriction.International journal of molecular sciences · 2026Review
180 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At implantation, the embryo expresses paternally derived alloantigens and evokes inflammation that can threaten reproductive success. To ensure a robust placenta and sustainable pregnancy, an active state of maternal immune tolerance mediated by CD4+ regulatory T cells (Tregs) is essential. Tregs operate to inhibit effector immunity, contain inflammation, and support maternal vascular adaptations, thereby facilitating trophoblast invasion and placental access to the maternal blood supply. Insufficient Treg numbers or inadequate functional competence are implicated in idiopathic infertility and recurrent miscarriage as well as later-onset pregnancy complications stemming from placental insufficiency, including preeclampsia and fetal growth restriction. In this Review, we summarize the mechanisms acting in the conception environment to drive the Treg response and discuss prospects for targeting the T cell compartment to alleviate immune-based reproductive disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.