Evidence map›Paper›PMID 30272559›Full record

ArticleeLife2018

KChIP3 coupled to Ca

Gerard Cantero-Recasens, Cristian M Butnaru, Miguel A Valverde, José R Naranjo, Nathalie Brouwers, Vivek Malhotra

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Purinergic agonists increase [CaAmerican journal of physiology. Cell physiology · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. The ulcerative colitis-associated gene FUT8 regulates the quantity and quality of secreted mucins.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Article
  11. CaFaculty reviews · 2022
    Review
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Gerard Cantero-RecasensCentre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID 0000-0001-6452-782X
Cristian M ButnaruCentre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.
Miguel A ValverdeLaboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, Spain.
José R NaranjoSpanish Network for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain.
Nathalie BrouwersCentre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID 0000-0002-9808-9394
Vivek MalhotraCentre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID 0000-0001-6198-7943
Centre for Genomic Regulation · ESBiomedical Research Networking Center on Neurodegenerative Diseases · ESInstitució Catalana de Recerca i Estudis Avançats · ESUniversitat Pompeu Fabra · ES

Funding

Centro de Excelencia Severo Ochoa 2013-2017 SEV-2012-0208Centro de Excelencia Severo Ochoa 2013-2017 SEV-2013-0347Maria de Maeztu Units of Excellence MDM-2015- 0502Ministerio de Economía y Competitividad BFU2013-44188-PMinisterio de Economía y Competitividad SAF2015-69762RMinisterio de Economía y Competitividad SAF2017-89554-R
6 · The paper itself

Abstract

Regulated mucin secretion from specialized goblet cells by exogenous agonist-dependent (stimulated) and -independent (baseline) manner is essential for the function of the epithelial lining. Over extended periods, baseline release of mucin can exceed quantities released by stimulated secretion, yet its regulation remains poorly characterized. We have discovered that ryanodine receptor-dependent intracellular Ca Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).

Indexed as

Calcium SignalingAnimalsCalciumColonGoblet CellsHEK293 CellsHT29 CellsHumansKv Channel-Interacting ProteinsMice, Inbred C57BLMice, KnockoutMicroscopy, ConfocalMucin 5ACSecretory VesiclesCalciumKv Channel-Interacting ProteinsMUC5AC protein, humanMucin 5ACbaseline mucin secretioncalcium oscillationscalcium sensorcell biologyhumanKChIP3mouseMUC5AC granules

Identifiers

PMID30272559
PMCPMC6167051
OpenAlexW2893781420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.