ArticleAngewandte Chemie (International ed. in English)2018
Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server.
Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Homogeneous catalysis in continuous flow integrating photocatalysis, electrocatalysis, and automation technologies.Communications chemistry · 2025Review
- Article
- Automated Optimization of a Multistep, Multiphase Continuous Flow Process for Pharmaceutical Synthesis.ACS sustainable chemistry & engineering · 2024Article
- Enhancing Lessons on the Internet of Things in Science, Technology, Engineering, and Medical Education with a Remote Lab.Sensors (Basel, Switzerland) · 2024Article
- Self-Driving Laboratories for Chemistry and Materials Science.Chemical reviews · 2024Review
- A dynamic knowledge graph approach to distributed self-driving laboratories.Nature communications · 2024Article
- Toward the Uniform of Chemical Theory, Simulation, and Experiments in Metaverse Technology.Precision chemistry · 2023Review
- Quid Pro Flow.Journal of the American Chemical Society · 2023Review
- Bayesian Self-Optimization for Telescoped Continuous Flow Synthesis.Angewandte Chemie (International ed. in English) · 2023Article
- Bayesian optimization-driven parallel-screening of multiple parameters for the flow synthesis of biaryl compounds.Communications chemistry · 2022Article
- Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self-Optimizing Flow Chemistry Platform.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Review
- Recent Advances in the Synthesis and Application of Polymer Compartments for Catalysis.Polymers · 2020Review
- The Medicinal Chemistry in the Era of Machines and Automation: Recent Advances in Continuous Flow Technology.Journal of medicinal chemistry · 2020Review
- Autonomous discovery of optically active chiral inorganic perovskite nanocrystals through an intelligent cloud lab.Nature communications · 2020Article
- Toward "On-Demand" Materials Synthesis and Scientific Discovery through Intelligent Robots.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Facilitating chemical and biochemical experiments with electronic microcontrollers and single-board computers.Nature protocols · 2020Article
- Automated radial synthesis of organic molecules.Nature · 2020Article
- The Fascinating Chemistry of α-Haloamides.ChemistryOpen · 2020Review
- Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server.Angewandte Chemie (International ed. in English) · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The power of the Cloud has been harnessed for pharmaceutical compound production with remote servers based in Tokyo, Japan being left to autonomously find optimal synthesis conditions for three active pharmaceutical ingredients (APIs) in laboratories in Cambridge, UK. A researcher located in Los Angeles, USA controlled the entire process via an internet connection. The constituent synthetic steps for Tramadol, Lidocaine, and Bupropion were thus optimized with minimal intervention from operators within hours, yielding conditions satisfying customizable evaluation functions for all examples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.