ArticleNucleic acids research2018
Cooperative translational control of polymorphic BAFF by NF90 and miR-15a.
Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- Foxg1 and companions: Not only transcription factors.Neural regeneration research · 2026Article
- Regulation of gene expression by alternative polyadenylation in health and disease.Nature reviews. Genetics · 2026Review
- Targeting RNA binding proteins with small-molecule inhibitors: Advances, challenges, and therapeutic opportunities.Acta pharmaceutica Sinica. B · 2026Review
- Smooth muscle NF90 deficiency ameliorates diabetic atherosclerotic calcification in male mice via FBXW7-AGER1-AGEs axis.Nature communications · 2024Article
- Post-transcriptional checkpoints in autoimmunity.Nature reviews. Rheumatology · 2023Review
- The Polyvalent Role of NF90 in RNA Biology.International journal of molecular sciences · 2022Review
- NF90 interacts with components of RISC and modulates association of Ago2 with mRNA.BMC biology · 2022Article
- Systematic identification of NF90 target RNAs by iCLIP analysis.Scientific reports · 2022Article
- circACTA2 mediates Ang II-induced VSMC senescence by modulation of the interaction of ILF3 with CDK4 mRNA.Aging · 2021Article
- Application of Genetic Studies to Flow Cytometry Data and Its Impact on Therapeutic Intervention for Autoimmune Disease.Frontiers in immunology · 2021Review
- Ribonucleoprotein Immunoprecipitation (RIP) Analysis.Bio-protocol · 2020Article
- Evolutionarily Selected Overexpression of the Cytokine BAFF Enhances Mucosal Immune Response AgainstFrontiers in immunology · 2020Article
- Aire Gene Influences the Length of the 3' UTR of mRNAs in Medullary Thymic Epithelial Cells.Frontiers in immunology · 2020Article
- NF90 stabilizes cyclin E1 mRNA through phosphorylation of NF90-Ser382 by CDK2.Cell death discovery · 2020Article
- Susceptibility of BAFF-var allele carriers to severe SLE with occurrence of lupus nephritis.BMC nephrology · 2019Article
- Identification of upstream miRNAs of SNAI2 and their influence on the metastasis of gastrointestinal stromal tumors.Cancer cell international · 2019Article
- NF90 regulation of immune factor expression in response to malaria antigens.Cell cycle (Georgetown, Tex.)Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Polymorphisms in untranslated regions (UTRs) of disease-associated mRNAs can alter protein production. We recently identified a genetic variant in the 3'UTR of the TNFSF13B gene, encoding the cytokine BAFF (B-cell-activating factor), that generates an alternative polyadenylation site yielding a shorter, more actively translated variant, BAFF-var mRNA. Accordingly, individuals bearing the TNFSF13B variant had higher circulating BAFF and elevated risk of developing autoimmune diseases. Here, we investigated the molecular mechanisms controlling the enhanced translation of BAFF-var mRNA. We identified nuclear factor 90 (NF90, also known as ILF3) as an RNA-binding protein that bound preferentially the wild-type (BAFF-WT mRNA) but not BAFF-var mRNA in human monocytic leukemia THP-1 cells. NF90 selectively suppressed BAFF translation by recruiting miR-15a to the 3'UTR of BAFF-WT mRNA. Our results uncover a paradigm whereby an autoimmunity-causing BAFF polymorphism prevents NF90-mediated recruitment of microRNAs to suppress BAFF translation, raising the levels of disease-associated BAFF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.