SynthesisThe journal of nutrition, health & aging2018
The Relationship between Anaemia and Frailty: A Systematic Review and Meta-Analysis of Observational Studies.
Synthesis in The journal of nutrition, health & aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 5 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Risk factors for frailty in older adults with cancer: a systematic review.BMC geriatrics · 2026Pooled it
- Applying the Bradford Hill Criteria to Assess the Independent Causal Roles of Aging and Medication in Frailty Progression: A Systematic Review.Drugs & aging · 2026Pooled it
- Risk factors for preoperative frailty in older patients with gastric cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Anaemia Is Associated with an Increased Risk of Fractures, a Systematic Review, and Meta-Analysis.Gerontology · 2023Pooled it
- Frailty Syndromes in Persons With Cerebrovascular Disease: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2019Pooled it
- An explainable online frailty prediction model for community-dwelling older adults based on machine learning algorithms: a cross-sectional study based on retrospective health data.Annals of medicine · 2026Article
- Association of preoperative hemoglobin levels with intraoperative hypotension: a retrospective cohort study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Article
- Sex differences in the prognostic value of body mass index after curative nephrectomy for high-risk renal cell carcinoma: a multicenter cohort study.International journal of clinical oncology · 2026Article
- Frailty-related factors and 1-year renal function change after sodium-glucose cotransporter-2 inhibitors in elderly chronic kidney disease patients.Kidney research and clinical practice · 2026Article
- Latent biochemical phenotypes delineate divergent health trajectories in older adults.npj aging · 2026Article
- Hepcidin in hospitalized older medical patients: associations with inflammation, anemia, frailty, comorbidity, and renal function.BMC geriatrics · 2026Article
- Frailty phenotype in adults with sickle cell disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Multimorbidity patterns and hospitalizations due to lower respiratory tract infections: a 15-year population-based cohort study.Age and ageing · 2026Article
- Personalised Long-Term Albumin Treatment Based on Three-Month Ascites Response in Patients With Decompensated Cirrhosis.Liver international : official journal of the International Association for the Study of the Liver · 2026Observational
- Association between nutrient intake and frailty status in Korean older adults: a cross-sectional study using the 9th (2022-2023) Korea National Health and Nutrition Examination Survey.Korean journal of community nutrition · 2026Article
- Incidence and Predictors of In-Hospital Frailty Progression in Patients with Chronic Limb-Threatening Ischemia after Endovascular Therapy: Results of the RIGEL Study.Journal of atherosclerosis and thrombosis · 2026Article
- Effects of an oral exercise intervention on pre-frailty or frailty in older people: a randomized clinical trial.Communications medicine · 2026Article
- Frailty and Cardiovascular Risk.European cardiology · 2026Review
- Frailty in older adults with chronic obstructive pulmonary disease: preliminary findings of prevalence and care priorities.BMC geriatrics · 2025Article
- Prevalence and causes of anemia among older adults in India: findings from wave 2 of the Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD).International journal for equity in health · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is increasing evidence that frailty may play a role in chronic diseases, but the associations with specific chronic disorders are still unclear.
objectivesTo conduct a systematic review and meta-analysis assessing the association of anaemia and frailty in observational studies.
methodsThe review was performed according to PRISMA guidelines. We searched PubMed, Web of Science, and Embase from 01/01/2002-10/09/2017. Pooled estimates were obtained through random effect models and Mantel-Haenszel weighting. Homogeneity was assessed with the I2 statistic. Publication bias was assessed with Egger's and Begg's tests.
resultsNineteen studies were included; two longitudinal, seventeen cross-sectional. All studies except three reported an association between anaemia and frailty. The pooled prevalence of prefrailty in individuals with anaemia was 49% (95% CI=38-59%; I2=89.96%) and 24% (95% CI=17-31%; I2= 94.78%) for frailty. Persons with anaemia had more than a twofold odds of frailty (pooled OR=2.24 95% CI=1.53-3.30; I2=91.8%). Only two studies longitudinally examined the association between anaemia and frailty, producing conflicting results.
conclusionsFrailty and prefrailty are common in anaemic persons. Older persons with anaemia have more than a two-fold increased odds of frailty. These results may have clinical implications, as they identify the need to assess frailty in anaemic people and investigate any potential negative effects associated with the co-occurrence of both conditions. Longitudinal research that examines temporal changes in anaemia and effect of treatment are needed to further clarify the relationship between anaemia and frailty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.