Evidence map›Paper›PMID 30272045›Full record

ArticleCurrent opinion in physiology2018

Presynaptic mechanisms controlling calcium-triggered transmitter release at the neuromuscular junction.

Markus Dittrich, Anne E Homan, Stephen D Meriney

Abstract read
In one paragraph

Article in Current opinion in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. L-type CaCellular and molecular neurobiology · 2022
    Article
  6. Article
  7. Primary and secondary motoneurons use different calcium channel types to control escape and swimming behaviors in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  8. Article
  9. Review
  10. Endogenous Tagging Reveals Differential Regulation of CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Markus DittrichBioTeam Inc., 7 Derosier Drive, Middleton, MA 01949.
Anne E HomanDepartment of Neuroscience, A210 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260.
Stephen D MerineyDepartment of Neuroscience, A210 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260.

Funding

CRCNS: Transmitter Release Site Organization in Plasticity and Disease at the NMJR01NS090644 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BLANPIED, THOMAS A, LAGHAEI, ROZITA · 2014 to 2018
$1.9M
Exercise-activated mechanisms reduce degeneration of aged neuromuscular junctionsR01AG051470 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MERINEY, STEPHEN D, NISHIMUNE, HIROSHI · 2015 to 2019
$1.9M
NIA NIH HHS R01 AG051470NINDS NIH HHS R01 NS090644
6 · The paper itself

Abstract

Calcium-triggered neurotransmission underlies most communication in the nervous system. Yet, despite the conserved and essential nature of this process, the molecular underpinnings of calcium-triggered neurotransmission have been difficult to study directly and our understanding to this date remains incomplete. Here we frame more recent efforts to understand this process with a historical perspective of the study of neurotransmitter release at the neuromuscular junction. We focus on the role of calcium channel distribution and organization relative to synaptic vesicles, as well as the nature of the calcium sensors that trigger release. Importantly, we provide a framework for understanding how the function of neurotransmitter release sites, or active zones, contributes to the function of the synapse as a whole.

Indexed as

active zonecalcium channelsneuromuscular junctionneurotransmitter releasepresynaptic

Identifiers

PMID30272045
PMCPMC6155978

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.