ArticleCommunications biology2018
Zinc deficiency causes delayed ATP clearance and adenosine generation in rats and cell culture models.
Article in Communications biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Impact of Zinc-Dependent Enzymes on Zinc Deficiency and Inflammatory Response in Ulcerative Colitis.Journal of gastroenterology and hepatology · 2026Observational
- Antidepressant-Related Signaling Pathways of Zinc Oxide Nanoparticles in a Mouse Model of Postpartum Depression.Biological trace element research · 2026Article
- The association between serum zinc level and clinical features in patients with inflammatory bowel disease.Journal of clinical biochemistry and nutrition · 2025Article
- Structure and Dynamics of ATP and the ATP-ZnThe journal of physical chemistry letters · 2024Article
- Impaired ATP hydrolysis in blood plasma contributes to age-related neutrophil dysfunction.Immunity & ageing : I & A · 2024Article
- Metalation and activation of ZnBiophysics reviews · 2023Review
- Pigmentation and TYRP1 expression are mediated by zinc through the early secretory pathway-resident ZNT proteins.Communications biology · 2023Article
- Zinc and Zinc Transporters in Dermatology.International journal of molecular sciences · 2022Review
- The impact of zinc supplementation on galectin-3 and metabolic markers in diabetic patients on hemodialysis: A randomized, double-blind, placebo-controlled trial.Journal of diabetes and metabolic disorders · 2022Article
- Zinc transport via ZNT5-6 and ZNT7 is critical for cell surface glycosylphosphatidylinositol-anchored protein expression.The Journal of biological chemistry · 2022Article
- Correlation between serum albumin and serum zinc in malignant lymphoma.Fujita medical journal · 2022Article
- Oral Zinc Supplementation Decreases the Risk of HCC Development in Patients With HCV Eradicated by DAA.Hepatology communications · 2021Article
- Detailed analyses of the crucial functions of Zn transporter proteins in alkaline phosphatase activation.The Journal of biological chemistry · 2020Article
- Zinc transporter 1 (ZNT1) expression on the cell surface is elaborately controlled by cellular zinc levels.The Journal of biological chemistry · 2019Article
- Biotin Is Required for the Zinc Homeostasis in the Skin.Nutrients · 2019Article
- Long-Term Zinc Supplementation Improves Liver Function and Decreases the Risk of Developing Hepatocellular Carcinoma.Nutrients · 2018Article
- Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis.Journal of immunology research · 2018Review
- Zinc transporters and their functional integration in mammalian cells.The Journal of biological chemistryReview
- Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer.Gastrointestinal tumorsArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc deficiency causes myriad pathophysiological symptoms, but why distinct phenotypes are generated by zinc deficiency remains unclear. Considering that several ectoenzymes involved in purinergic signaling through extracellular adenine-nucleotide hydrolysis possess zinc ions in their active sites, and disorders in purinergic signaling result in diverse diseases that are frequently similar to those caused by zinc deficiency, herein we examine whether zinc deficiency affects extracellular adenine-nucleotide metabolism. Zinc deficiency severely impairs the activities of major ectoenzymes (ENPP1, ENPP3, NT5E/CD73, and TNAP), and also strongly suppresses adenine-nucleotide hydrolysis in cell-membrane preparations or rat plasma, thereby increasing ATP and ADP levels and decreasing adenosine levels. Thus, zinc deficiency delays both extracellular ATP clearance and adenosine generation, and zinc modulates extracellular adenine-nucleotide metabolism. Since the finely tuned balance between extracellular adenine nucleotides and adenosine is critical for purinergic signaling, these findings provide a novel insight into why zinc deficiency results in diverse symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.