Evidence map›Paper›PMID 30271964›Full record

ArticleCommunications biology2018

Vesicle-associated membrane protein 7-mediated eosinophil degranulation promotes allergic airway inflammation in mice.

Lian Willetts, Lindsey C Felix, Elizabeth A Jacobsen, Lakshmi Puttagunta, Rachel M Condjella, Katie R Zellner, Sergei I Ochkur, John D Kim, Huijun Luo, Nancy A Lee and 3 more

Abstract read
In one paragraph

Article in Communications biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Eosinophil extracellular traps in respiratory ailment: Pathogenic mechanisms and clinical translation.World journal of otorhinolaryngology - head and neck surgery · 2024
    Review
  5. Review
  6. Review
  7. Article
  8. The Enigma of Eosinophil Degranulation.International journal of molecular sciences · 2021
    Review
  9. Article
  10. [Effect of CCR3 gene on related inflammatory cells in respiratory allergic diseases].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021
    Review
  11. Review
  12. Assessment of Lung Eosinophils In Situ Using Immunohistological Staining.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lian WillettsAlberta Respiratory Centre (ARC) Research, Department of Medicine, University of Alberta, Edmonton, T6G 2S2, Alberta, Canada.
Lindsey C FelixAlberta Respiratory Centre (ARC) Research, Department of Medicine, University of Alberta, Edmonton, T6G 2S2, Alberta, Canada.ORCID http://orcid.org/0000-0001-7335-9792
Elizabeth A JacobsenDivision of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, 85259, AZ, USA.
Lakshmi PuttaguntaDepartment of Laboratory Medicine & Pathology, University of Alberta, Edmonton, T6G 2B7, Alberta, Canada.
Rachel M CondjellaDivision of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, 85259, AZ, USA.
Katie R ZellnerDivision of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, 85259, AZ, USA.
Sergei I OchkurDivision of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, 85259, AZ, USA.
John D KimAlberta Respiratory Centre (ARC) Research, Department of Medicine, University of Alberta, Edmonton, T6G 2S2, Alberta, Canada.
Huijun LuoDivision of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, 85259, AZ, USA.
Nancy A LeeDivision of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, 85259, AZ, USA.
James J LeeDivision of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, 85259, AZ, USA.
Redwan MoqbelDepartment of Immunology, University of Manitoba, Winnipeg, R3T 2N2, Manitoba, Canada.
Paige LacyAlberta Respiratory Centre (ARC) Research, Department of Medicine, University of Alberta, Edmonton, T6G 2S2, Alberta, Canada. placy@ualberta.ca.

Funding

EOSINOPHIL ACTIVITIES IN MURINE MODELS OF LUNG DISEASER01HL065228 · NHLBI · MAYO CLINIC COLL OF MED, MAYO CLINIC AZ · PI JACOBSEN, ELIZABETH A · 2000 to 2017
$6.7M
MOUSE MODELS OF EOSINOPHIL ASSOCIATED LUNG DYSFUNCTIONR01HL058723 · NHLBI · MAYO CLINIC COLL OF MED, MAYO CLINIC AZ · PI LEE, NANCY A. · 1998 to 2013
$4.2M
Mouse Models of Eosinophil-Associated Lung DysfunctionR56HL058723 · NHLBI · MAYO CLINIC ARIZONA · PI LEE, NANCY A. · 2008 to 2008
$400k
NHLBI NIH HHS R01 HL058723NHLBI NIH HHS R01 HL065228NHLBI NIH HHS R56 HL058723
6 · The paper itself

Abstract

Eosinophil degranulation is a determining factor in allergy-mediated airway pathology. Receptor-mediated degranulation in eosinophils requires vesicle-associated membrane protein 7 (VAMP-7), a principal component of the SNARE fusion machinery. The specific contribution of eosinophil degranulation to allergen-induced airway responses remains poorly understood. We generated mice with

Identifiers

PMID30271964
PMCPMC6123774

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.