ArticleCommunications biology2018
A general model of focal adhesion orientation dynamics in response to static and cyclic stretch.
Article in Communications biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Cyclic stretch induces autophagy-mediated focal adhesion remodeling and activates mitochondria.Life science alliance · 2026Article
- Multiscale modelling shows how cell-ECM interactions impact ECM fibre alignment and cell detachment.PLoS computational biology · 2025Article
- Sonomechanobiology: Vibrational stimulation of cells and its therapeutic implications.Biophysics reviews · 2023Review
- A Statistical Mechanics Approach to Describe Cell Reorientation Under Stretch.Bulletin of mathematical biology · 2023Article
- The effect of cyclic stretch on aortic viscoelasticity and the putative role of smooth muscle focal adhesion.Frontiers in physiology · 2023Article
- Growth kinetics and power laws indicate distinct mechanisms of cell-cell interactions in the aggregation process.Biophysical journal · 2022Article
- Efficient flocking: metric versus topological interactions.Royal Society open science · 2021Article
- High Pulsatile Load Decreases Arterial Stiffness: AnFrontiers in physiology · 2021Article
- Materials for blood brain barrier modelingMaterials science & engineering. R, Reports : a review journal · 2020Article
- Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury.Frontiers in physiology · 2019Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding cellular response to mechanical forces is immensely important for a plethora of biological processes. Focal adhesions are multimolecular protein assemblies that connect the cell to the extracellular matrix and play a pivotal role in cell mechanosensing. Under time-varying stretches, focal adhesions dynamically reorganize and reorient and as a result, regulate the response of cells in tissues. Here I present a simple theoretical model based on, to my knowledge, a novel approach in the understanding of stretch-sensitive bond association and dissociation processes together with the elasticity of the cell-substrate system to predict the growth, stability, and the orientation of focal adhesions in the presence of static as well as cyclically varying stretches. The model agrees well with several experimental observations; most importantly, it explains the puzzling observations of parallel orientation of focal adhesions under static stretch and nearly perpendicular orientation in response to fast varying cyclic stretch.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.