ArticleCommunications biology2018
Small sample sizes reduce the replicability of task-based fMRI studies.
Article in Communications biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06606925 (Determining Which Regions of the Brain Are Active During Flight Simulation at Separate Timepoints During Training), which is not on this map. Cited by 190 papers, 18 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Determining Which Regions of the Brain Are Active During Flight Simulation at Separate Timepoints During Training
Who cites it
190 citing papers in PubMed, 18 syntheses or guidelines pooled it.
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- The Neural Correlates of Body Image Processing in Anorexia Nervosa and Bulimia Nervosa: An Activation Likelihood Estimation Meta-Analysis of fMRI Studies.International journal of environmental research and public health · 2025Pooled it
- Psychopathy and medial frontal cortex: A systematic review reveals predominantly null relationships.Neuroscience and biobehavioral reviews · 2024Pooled it
- Effectiveness of Psychobiotics in the Treatment of Psychiatric and Cognitive Disorders: A Systematic Review of Randomized Clinical Trials.Nutrients · 2024Pooled it
- Parameter Space and Potential for Biomarker Development in 25 Years of fMRI Drug Cue Reactivity: A Systematic Review.JAMA psychiatry · 2024Pooled it
- A research agenda for understanding how social inequality is linked to brain structure and function.Nature human behaviour · 2024Pooled it
- Highlight results, don't hide them: Enhance interpretation, reduce biases and improve reproducibility.NeuroImage · 2023Pooled it
- The rediscovered motor-related area 55b emerges as a core hub of music perception.Communications biology · 2022Pooled it
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- Evaluation of thresholding methods for activation likelihood estimation meta-analysis via large-scale simulations.Human brain mapping · 2022Pooled it
- Identifying a brain network for musical rhythm: A functional neuroimaging meta-analysis and systematic review.Neuroscience and biobehavioral reviews · 2022Pooled it
- Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review.Pharmacological reviews · 2022Pooled it
- The neural underpinnings of intergroup social cognition: an fMRI meta-analysis.Social cognitive and affective neuroscience · 2021Pooled it
- A systematic review of neuroimaging and acute cannabis exposure in age-of-risk for psychosis.Translational psychiatry · 2021Pooled it
- The neurobiological reward system in Prolonged Grief Disorder (PGD): A systematic review.Psychiatry research. Neuroimaging · 2020Pooled it
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- Empirical assessment of changing sample-characteristics in task-fMRI over two decades: An example from gustatory and food studies.Human brain mapping · 2020Pooled it
- Aerobic walking exercise training boosts thalamic connectivity in MS patients with cognitive processing speed impairment.Brain and cognition · 2025Trial
- The role of anterior and posterior insula in male genital response and in visual attention: an exploratory multimodal fMRI study.Scientific reports · 2020Trial
130 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite a growing body of research suggesting that task-based functional magnetic resonance imaging (fMRI) studies often suffer from a lack of statistical power due to too-small samples, the proliferation of such underpowered studies continues unabated. Using large independent samples across eleven tasks, we demonstrate the impact of sample size on replicability, assessed at different levels of analysis relevant to fMRI researchers. We find that the degree of replicability for typical sample sizes is modest and that sample sizes much larger than typical (e.g.,
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.