ArticleLetters in biomathematics2018
Modelling acute myeloid leukaemia in a continuum of differentiation states.
Article in Letters in biomathematics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Longitudinal Single-Cell RNA-Sequencing Reveals Evolution of Micro- and Macro-states in Chronic Myeloid Leukemia.Cancer research · 2026Article
- Modeling the evolutionary dynamics of clonal hematopoiesis.Nature genetics · 2026Review
- Cell State Transitions Drive the Evolution of Disease Progression in B-Lymphoblastic Leukemia.Cancer research communications · 2026Article
- Detection of continuous hierarchical heterogeneity by single-cell surface antigen analysis in the prognosis evaluation of acute myeloid leukaemia.BMC bioinformatics · 2023Article
- Single-cell multi-omics and lineage tracing to dissect cell fate decision-making.Stem cell reports · 2023Review
- An integrative systems biology approach to overcome venetoclax resistance in acute myeloid leukemia.PLoS computational biology · 2022Article
- Comparison of cell state models derived from single-cell RNA sequencing data: graph versus multi-dimensional space.Mathematical biosciences and engineering : MBE · 2022Article
- Theoretical modeling of collaterally sensitive drug cycles: shaping heterogeneity to allow adaptive therapy.Journal of mathematical biology · 2021Article
- Differentiation of leukemic blasts is not completely blocked in acute myeloid leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Opportunities for improving cancer treatment using systems biology.Current opinion in systems biology · 2019Article
- Inferring population dynamics from single-cell RNA-sequencing time series data.Nature biotechnology · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Here we present a mathematical model of movement in an abstract space representing states of cellular differentiation. We motivate this work with recent examples that demonstrate a continuum of cellular differentiation using single cell RNA sequencing data to characterize cellular states in a high-dimensional space, which is then mapped into
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.