Evidence map›Paper›PMID 30271847›Full record

ArticleRegenerative therapy2017

Transplanted mesenchymal stem cells are effective for skin regeneration in acute cutaneous wounds of pigs.

Hiroko Ochiai, Kazuo Kishi, Yoshiaki Kubota, Aiko Oka, Eri Hirata, Hanayo Yabuki, Yoshitaka Iso, Hiroshi Suzuki, Akihiro Umezawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. CD44 signaling in skin wound healing and regeneration.Journal of translational medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hiroko OchiaiDepartment of Plastic and Reconstructive Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, 152-8902 Japan.
Kazuo KishiDepartment of Plastic and Reconstructive Surgery, Keio University Hospital, Tokyo, 160-8582 Japan.
Yoshiaki KubotaDepartment of Vascular Biology, The Sakaguchi Laboratory, Keio University School of Medicine, Tokyo 160-8582 Japan.
Aiko OkaDepartment of Plastic and Reconstructive Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, 152-8902 Japan.
Eri HirataDepartment of Plastic and Reconstructive Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, 152-8902 Japan.
Hanayo YabukiDepartment of Plastic and Reconstructive Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, 152-8902 Japan.
Yoshitaka IsoShowa University Research Institute for Sport and Exercise Sciences, Kanagawa, 227-8501 Japan.
Hiroshi SuzukiDivision of Cardiology, Department of Internal Medicine, Showa University Fujigaoka Hospital, Kanagawa, 227-8501 Japan.
Akihiro UmezawaDepartment of Reproductive Biology and Pathology, National Center for Child Health and Development, Tokyo, 157-0074 Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe investigated the effects of mesenchymal stem cells (MSCs) on cutaneous wound healing in pigs in order to develop new therapies to enhance wound healing in humans.

methodsWe cultured bone marrow cells from the femurs of male pigs, and the multipotency of these cells were then confirmed. The characteristics of the cultured cells were determined by flow cytometric analyses. The MSCs were injected intradermally into the skin of pigs as auto-transplantation, and linear full-thickness incisional wounds were made through the injected area immediately afterward.

resultsThe MSCs were found to be positive for SWC3a, CD44, SLA class I, CD29, CD44H, and CD90. At 28 days post-surgery, wounds treated with MSCs had healed well, with only very fine scars visible macroscopically. Histologically, collagen architecture was thick and elastic fibers appeared in the wounds. Histomorphologic scale analysis demonstrated that the wounds treated with MSCs scored better than the controls. Significantly larger fibroblasts were observed in the wounds treated with MSCs than controls.

conclusionThese results indicate that transplantation of MSCs causes wounds to heal almost completely, possible indicating regeneration to normal skin. We hypothesize that the transplantation protocol described in this study may also be applicable to human wound healing.

Indexed as

Bone marrowCollagen fiberCutaneous wound healingMesenchymal stem cellsPigWound regeneration

Identifiers

PMID30271847
PMCPMC6134893

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.