ArticleCanadian journal of gastroenterology & hepatology2018
The Effect of Antidepressants on the Course of Inflammatory Bowel Disease.
Article in Canadian journal of gastroenterology & hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Psychopharmacological Therapy Positively Modulates Disease Activity in Inflammatory Bowel Disease: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Successful Collection of Patient-Reported Outcomes Shows Improvement in Quality of Life, Depression, and Disease Activity among Patients with Inflammatory Bowel Disease: A Real-World Study.Crohn's & colitis 360 · 2025Article
- iACT4IBD: a randomised controlled trial of a brief online intervention based on acceptance and commitment therapy to improve wellbeing for adults with inflammatory bowel disease.Frontiers in digital health · 2025Article
- The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients.Journal of clinical medicine · 2024Review
- From gut to brain: understanding the role of microbiota in inflammatory bowel disease.Frontiers in immunology · 2024Review
- [Brain-Gut-Microbiota Axis].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2023Review
- Interplay between Serotonin, Immune Response, and Intestinal Dysbiosis in Inflammatory Bowel Disease.International journal of molecular sciences · 2022Review
- Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment.Nature reviews. Gastroenterology & hepatology · 2022Review
- Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics.BMC medicine · 2022Article
- The Role of Brain-Derived Neurotrophic Factor in Immune-Related Diseases: A Narrative Review.Journal of clinical medicine · 2022Review
- Concurrent functional gastrointestinal disorders in patients with inflammatory bowel disease.Frontiers in gastroenterology (Lausanne, Switzerland) · 2022Review
- Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut-brain communications.Frontiers in immunology · 2022Review
- Health Maintenance Consensus for Adults With Inflammatory Bowel Disease.Inflammatory bowel diseases · 2021Article
- The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases.Journal of clinical medicine · 2021Review
- Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota-Gut-Brain Axis.Frontiers in endocrinology · 2021Review
- Altered brain structural connectivity in patients with longstanding gut inflammation is correlated with psychological symptoms and disease duration.NeuroImage. Clinical · 2021Article
- The Relationship Between Autonomic Dysfunction of the Gastrointestinal Tract and Emotional Distress in Patients With Systemic Sclerosis.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2021Article
- Serum Serotonin Differentiates Between Disease Activity States in Crohn's Patients.Inflammatory bowel diseases · 2020Article
- Managing Pain and Psychosocial Care in IBD: a Primer for the Practicing Gastroenterologist.Current gastroenterology reports · 2020Review
- Antidepressants in inflammatory bowel disease.Nature reviews. Gastroenterology & hepatology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Mood may have an important role in the natural history of inflammatory bowel disease (IBD). However, the impact of antidepressant use on prognosis is unknown. We aimed to address this in a longitudinal study in a referral population. Methods: We collected demographic data, clinical disease activity and mood using validated questionnaires, and antidepressant use at baseline. Longitudinal disease activity was defined by disease flare or need for glucocorticosteroids, escalation of medical therapy, hospitalisation, or intestinal resection. We compared rates of these over a minimum period of 2 years according to antidepressant use at baseline. Results: In total, 331 patients provided complete data, of whom 54 (15.8%) were taking an antidepressant at study entry. Older age, female gender, and abnormal mood scores were associated with antidepressant use. During longitudinal follow-up, there was a trend towards lower rates of any of the four endpoints of IBD activity of interest in patients with abnormal anxiety scores at baseline and who were receiving an antidepressant (42.3% versus 64.6%, P = 0.05). Based on univariate Cox regression analysis, there was a trend towards lower rates of escalation of medical therapy among patients receiving antidepressants at baseline (hazard ratio (HR) = 0.59; 95% confidence interval (CI) 0.35-1.00, P = 0.05). None of the differences observed persisted after multivariate Cox regression. Conclusions: Antidepressants may have some beneficial effects on the natural history of IBD, but larger studies with longer follow-up are required. Whether these effects are limited to patients with abnormal mood remains uncertain.
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Registered trials
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