Evidence map›Paper›PMID 30271672›Full record

ArticleNature biomedical engineering2018

Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells.

Bohao Liu, Benjamin W Lee, Koki Nakanishi, Aranzazu Villasante, Rebecca Williamson, Jordan Metz, Jinho Kim, Mariko Kanai, Lynn Bi, Kristy Brown and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 214 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
214citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

214 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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154 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Bohao LiuCollege of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-9107-8839
Benjamin W LeeCollege of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0003-1319-0563
Koki NakanishiDepartment of Medicine, Columbia University, New York, NY, USA.
Aranzazu VillasanteDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-7919-9670
Rebecca WilliamsonCollege of Physicians and Surgeons, Columbia University, New York, NY, USA.
Jordan MetzCollege of Physicians and Surgeons, Columbia University, New York, NY, USA.
Jinho KimDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Mariko KanaiDepartment of Medicine, Columbia University, New York, NY, USA.
Lynn BiDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Kristy BrownDepartment of Pathology and Cell Biology, Columbia University, New York, NY, USA.
Gilbert Di PaoloDepartment of Pathology and Cell Biology, Columbia University, New York, NY, USA.
Shunichi HommaDepartment of Medicine, Columbia University, New York, NY, USA.
Peter A SimsDepartment of Systems Biology, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-3921-4837
Veli K TopkaraDepartment of Medicine, Columbia University, New York, NY, USA.
Gordana Vunjak-NovakovicDepartment of Medicine, Columbia University, New York, NY, USA. gv2131@columbia.edu.ORCID http://orcid.org/0000-0002-9382-1574

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007367 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI REINER, STEVEN L · 1985 to 2021
$25.1M
Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
Engineering Vascularized Cardiac MuscleR01HL076485 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Gordana Vunjak-Novakovic · 2005 to 2026
$9.2M
Tissue Chips for Rare Disease: Adding Timothy Syndrome to the HeLIVaSkCa platformUH3EB017103 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI VUNJAK-NOVAKOVIC, GORDANA · 2014 to 2016
$7.1M
Multi-tissue platform for modeling systemic pathologiesUG3EB025765 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI VUNJAK-NOVAKOVIC, GORDANA · 2017 to 2019
$2.8M
Integrated heart-liver-vascular systems for drug testing in human health and diseUH2EB017103 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI VUNJAK-NOVAKOVIC, GORDANA · 2012 to 2013
$1.7M
APP ubiquitination and implications for AB generationF30AG047748 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WILLIAMSON, REBECCA LYNN · 2014 to 2017
$180k
NHLBI NIH HHS R01 HL076485NIA NIH HHS F30 AG047748NIBIB NIH HHS P41 EB002520NIBIB NIH HHS UG3 EB025765NIBIB NIH HHS UH3 EB017103NIGMS NIH HHS T32 GM007367
6 · The paper itself

Abstract

The ability of extracellular vesicles (EVs) to regulate a broad range of cellular processes has recently been exploited for the treatment of diseases. For example, EVs secreted by stem cells injected into infarcted hearts can induce recovery through the delivery of stem-cell-specific miRNAs. However, the retention of the EVs and the therapeutic effects are short-lived. Here, we show that an engineered hydrogel patch capable of slowly releasing EVs secreted from cardiomyocytes derived from induced pluripotent stem (iPS) cells reduced arrhythmic burden, promoted ejection-fraction recovery, decreased cardiomyocyte apoptosis 24 hours after infarction, and reduced infarct size and cell hypertrophy 4 weeks post-infarction when implanted onto infarcted rat hearts. We also show that the EVs are enriched with cardiac-specific miRNAs known to modulate cardiomyocyte-specific processes. The extended delivery of EVs secreted from iPS-cell-derived cardiomyocytes into the heart may help understand heart recovery and treat heart injury.

Identifiers

PMID30271672
PMCPMC6159913

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.