Evidence map›Paper›PMID 30271641›Full record

ArticleCase reports in hematology2018

Concurrent Diagnosis of Chronic Myeloid Leukemia and Follicular Lymphoma: An Unreported Presentation.

Amy G Starr, Sushma R Jonna, Joeffrey J Chahine, Bhaskar V Kallakury, Chaitra S Ujjani

Open access · goldAbstract readCase Reports
In one paragraph

Article in Case reports in hematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amy G StarrMedStar Georgetown University Hospital, Department of Pathology, 3800 Reservoir Rd NW, Medical Dental Building, SE 200, Washington, DC 20007, USA.ORCID 0000-0001-9894-4058
Sushma R JonnaLombardi Comprehensive Cancer Center, Department of Hematology and Oncology, MedStar Georgetown University Hospital, 3800 Reservoir Rd. NW, Washington, DC 20007, USA.
Joeffrey J ChahineMedStar Georgetown University Hospital, Department of Pathology, 3800 Reservoir Rd NW, Medical Dental Building, SE 200, Washington, DC 20007, USA.
Bhaskar V KallakuryMedStar Georgetown University Hospital, Department of Pathology, 3800 Reservoir Rd NW, Medical Dental Building, SE 200, Washington, DC 20007, USA.
Chaitra S UjjaniLombardi Comprehensive Cancer Center, Department of Hematology and Oncology, MedStar Georgetown University Hospital, 3800 Reservoir Rd. NW, Washington, DC 20007, USA.
Georgetown University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymphadenopathy in chronic myeloid leukemia (CML) is usually due to extramedullary involvement with accelerated or blast phases of the disease. The occurrence of non-Hodgkin lymphoma (NHL) as a synchronous malignancy with CML is rare. We report a case of a 73-year-old male who presented with dyspnea and right-sided lower extremity edema in the setting of leukocytosis. Bone marrow evaluation indicated a chronic phase chronic myeloid leukemia (CML), confirmed by molecular testing. Imaging of the chest for persistent dyspnea revealed supraclavicular and mediastinal lymphadenopathy. Biopsy of the cervical node showed expanded lymphoid follicles with atypical germinal centers that were positive for CD10, BCL-2, and BCL-6, consistent with follicular lymphoma (FL). Nodal PCR demonstrated clonal IGH and IGK gene rearrangements, and FISH analysis was positive for IGH-BCL-2 fusion. Together, these tests supported the diagnosis of FL. Additionally, the lymph node showed paracortical expansion by maturing pan-hematopoietic elements, no blastic groups, and positive RT-PCR analysis for BCR-ABL1, indicating concomitant involvement by chronic phase-CML. To our knowledge, this is the first reported case of a patient with a concurrent diagnosis of CML and FL.

Identifiers

PMID30271641
PMCPMC6151199
OpenAlexW2891021568

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.