Evidence map›Paper›PMID 30271580›Full record

ArticleF1000Research2018

Antimicrobial peptide LL-37 and recombinant human mannose-binding lectin express distinct age- and pathogen-specific antimicrobial activity in human newborn cord blood

Annette Scheid, Ning Li, Carleen Jeffers, Francesco Borriello, Sweta Joshi, Al Ozonoff, Matthew Pettengill, Ofer Levy

Open access · goldAbstract read
In one paragraph

Article in F1000Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Annette ScheidDepartment of Pediatric Newborn Medicine, Brigham and Women's University Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-9986-5546
Ning LiPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Carleen JeffersPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Francesco BorrielloPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Sweta JoshiPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Al OzonoffPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Matthew PettengillPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Ofer LevyPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Boston Children's Hospital · USBrigham and Women's Hospital · USBroad Institute · US

Funding

Transcriptomics to define biomarkers of neonatal vaccine immunogenicityU19AI118608 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2017 to 2021
$24.7M
Dissecting the mechanism of age-specific adjuvant synergy in vitro and in vivoU01AI124284 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2016 to 2020
$2.9M
Modeling distinct neonatal purine metabolism to inform vaccine developmentR01AI100135 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2012 to 2016
$2.5M
Adenosine Shapes Neonatal Toll-like Receptor FunctionR01AI067353 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2006 to 2010
$2.1M
NIAID NIH HHS HHSN272201400052CNIAID NIH HHS R01 AI067353NIAID NIH HHS R01 AI100135NIAID NIH HHS U01 AI124284NIAID NIH HHS U19 AI118608
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antimicrobial Cationic PeptidesCandida albicansCathelicidinsFemaleFetal BloodGestational AgeHumansInfant, NewbornMaleMannose-Binding LectinRecombinant ProteinsStaphylococcus aureusStaphylococcus epidermidisAntimicrobial Cationic PeptidesCathelicidinsMannose-Binding LectinRecombinant ProteinsAntimicrobial ActivityCord BloodLL-37Mannose Binding LectinNewbornPreterm

Identifiers

PMID30271580
PMCPMC6143923
OpenAlexW2803379837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.