Evidence map›Paper›PMID 30271515›Full record

ArticleBiomicrofluidics2018

Microfluidic approaches for cell-based molecular diagnosis.

Dong Jun Lee, John Mai, Tony Jun Huang

Erratum issuedAbstract read
In one paragraph

Article in Biomicrofluidics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Human-Device Interaction in the Life Science Laboratory.Advances in biochemical engineering/biotechnology · 2022
    Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Dong Jun LeeDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.
John MaiAlfred E. Mann Institute for Biomedical Engineering, University of Southern California, Los Angeles, California 90089, USA.ORCID 0000-0001-8001-9120

Funding

Extracellular vesicles and their ncRNA cargo as markers of trophoblast injuryR01HD086325 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI SADOVSKY, YOEL · 2015 to 2019
$3.6M
ExoSOUND: An Acoustofluidic Device for Exosome IsolationR44GM125439 · NIGMS · ASCENT BIO-NANO TECHNOLOGIES, INC. · PI WANG, LIN · 2017 to 2018
$1.9M
An Acoustofluidic Device for Point-of-Care Sputum Processing and AnalysisR44HL126441 · NHLBI · ASCENT BIO-NANO TECHNOLOGIES, INC. · PI WANG, LIN · 2016 to 2017
$1.5M
Single-Cell VirologyR01AI120560 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI CAMERON, CRAIG E., HUANG, TONY JUN · 2015 to 2017
$1.4M
NHLBI NIH HHS R44 HL126441NIAID NIH HHS R01 AI120560NICHD NIH HHS R01 HD086325NIGMS NIH HHS R44 GM125439
6 · The paper itself

Abstract

The search for next-generation biomarkers has enabled cell-based diagnostics in a number of disciplines ranging from oncology to pharmacogenetics. However, cell-based diagnostics are still far from clinical reality due to the complex assays and associated protocols which typically require cell isolation, lysis, DNA extraction, amplification, and detection steps. Leveraging recent advances in microfluidics, many biochemical assays have been translated onto microfluidic platforms. We have compared and summarized recent advances in modular approaches toward the realization of fully-integrated, cell-based molecular diagnostics for clinical and point-of-care applications.

Identifiers

PMID30271515
PMCPMC6138474

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.