ArticleAnesthesiology research and practice2018
Comparison between Vapocoolant Spray and Eutectic Mixture of Local Anesthetics Cream in Reducing Pain during Spinal Injections.
Article in Anesthesiology research and practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The Effect of Lidocaine-Prilocaine Cream Combined with or Without Remimazolam on VAS and APAIS Anxiety Score in Patient Undergoing Spinal Anesthesia.Drug design, development and therapy · 2024Trial
- The impact of a topical spray of lidocaine 10% on maternal satisfaction prior to spinal needle insertion for cesarean delivery in North India: a prospective, randomized, double-blind, placebo-controlled trial.Anesthesia and pain medicine · 2026Article
- Comparing ethyl chloride and 10% lignocaine spray for pediatric intravenous cannulation pain relief.Clinical and experimental pediatrics · 2026Article
- Hand Surgery Anaesthesia Innovations: Balancing Efficiency, Cost, and Comfort with WALANT, Ultrasound, and Emerging Adjuncts-A Narrative Review.Journal of clinical medicine · 2025Review
- Effectiveness of vapocoolant spray compared to eutectic lidocaine/prilocaine cream to enhance tolerance during intravenous catheterisation: a randomised controlled trial.The Journal of small animal practice · 2025Article
- Comparison between Hugo point acupressure and vapocoolant spray on pain intensity during needle insertion into arteriovenous fistula in hemodialysis patients: A randomized controlled trial.Journal of education and health promotion · 2025Article
- Efficacy of ShotBlocker device versus vapocoolant spray for spinal needle pain relief during spinal anaesthesia in elective caesarean section - A randomised controlled trial.Indian journal of anaesthesia · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEutectic mixture of local anesthetics (EMLA) cream is often used for local anesthesia during spinal injections. However, this agent has delayed onset of action while vapocoolant spray serves more advantages. The vapocoolant spray containing ethyl chloride has fast onset and is safe, low cost, and widely available. This study aimed at comparing the effectiveness of vapocoolant spray and EMLA cream in reducing pain for spinal injections.
methodsThis was an experimental study on 94 subjects with 47 subjects treated with EMLA cream and 47 subjects treated with vapocoolant spray. The effectiveness of anesthesia was assessed by using Numeric Pain Rating Scale (NPRS) and patient movement during the surgery.
resultsThis study found that the pain scale was NPRS 0 (0-3) for the EMLA group and NPRS 0 (0-4) for the vapocoolant spray group. There was no significant difference between two groups for pain scale according to the Mann-Whitney
conclusionsBoth EMLA cream and vapocoolant spray were equally effective in reducing pain during spinal injection. There was no difference in degree of pain reduction and patient movement between the EMLA cream group and the vapocoolant spray group during spinal injection.
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Registered trials
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