ArticleScience China. Chemistry2018
Engineering a customized nanodrug delivery system at the cellular level for targeted cancer therapy.
Article in Science China. Chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Ultra-Stable Topological Telluride Monolayers for Next-Generation Battery Anodes and Sulfur Hosts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Organic room temperature phosphorescence co-crystal with reversible acid/base stimulus response.Smart molecules : open access · 2025Article
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- Stretchable Full-Color Phosphorescent PVA-Based Ionogels for Multimodal Sensing-Visual Integration Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- [Advances in mapping analysis of ribonucleic acid modifications through sequencing].Se pu = Chinese journal of chromatography · 2024Review
- Review
- Aptamer-engineered (nano)materials for theranostic applications.Theranostics · 2023Review
- Bimetallic Mixed Clusters Highly Loaded on Porous 2D Graphdiyne for Hydrogen Energy Conversion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Emerging 2D Nanomaterials for Biomedical Applications.Materials today (Kidlington, England) · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Drug administration customized to individual cells could intrinsically address cancer heterogeneity and provide a safe and effective method for delivering personalized treatment. To accomplish this, we developed a smart nanodrug delivery system characterized by cancer cell-targeted drug delivery and intracellular biomarker-responsive drug activation. This system was composed of a long-nicked DNA duplex formed by tandem hybridization of two extended antisense oligonucleotides whose ends were separately blocked with a cancer cell-specific aptamer, AS1411, and a replaceable anti-biomarker probe (ABP). We demonstrated that this DNA nanodrug was directed to cancer cells with the guidance power of AS1411 and then activated by the presence of a given intracellular biomarker. By using such a belt-and-braces strategy, this DNA nanodrug system could safely and efficiently accelerate apoptosis of target cancer cells. Moreover, since the expression level of biomarkers tends to indicate the specific physiological state of individual cells, biomarker-responsive activation of the nanodrug is expected to enable customized drug administration at the cellular level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.