Evidence map›Paper›PMID 30271410›Full record

ArticleFrontiers in immunology2018

The Diversity of Mammalian Hemoproteins and Microbial Heme Scavengers Is Shaped by an Arms Race for Iron Piracy.

Alessandra Mozzi, Diego Forni, Mario Clerici, Rachele Cagliani, Manuela Sironi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Iron nutrition and COVID-19 among Nigerian healthcare workers.Evolution, medicine, and public health · 2024
    Article
  2. Review
  3. Review
  4. Antimicrobial Activity of Metals and Metalloids.Annual review of microbiology · 2021
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alessandra MozziScientific Institute, IRCCS E. Medea, Bioinformatics, Lecco, Italy.
Diego ForniScientific Institute, IRCCS E. Medea, Bioinformatics, Lecco, Italy.
Mario ClericiDepartment of Physiopathology and Transplantation, University of Milan, Milan, Italy.
Rachele CaglianiScientific Institute, IRCCS E. Medea, Bioinformatics, Lecco, Italy.
Manuela SironiScientific Institute, IRCCS E. Medea, Bioinformatics, Lecco, Italy.
IRCCS Eugenio Medea · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron is an essential micronutrient for most living species. In mammals, hemoglobin (Hb) stores more than two thirds of the body's iron content. In the bloodstream, haptoglobin (Hp) and hemopexin (Hpx) sequester free Hb or heme. Pathogenic microorganisms usually acquire iron from their hosts and have evolved complex systems of iron piracy to circumvent nutritional immunity. Herein, we performed an evolutionary analysis of genes coding for mammalian heme-binding proteins and heme-scavengers in pathogen species. The underlying hypothesis is that these molecules are engaged in a molecular arms race. We show that positive selection drove the evolution of mammalian Hb and Hpx. Positively selected sites in Hb are located at the interaction surface with

Indexed as

AnimalsBacterial ProteinsCation Transport ProteinsHaemophilus influenzaeHaptoglobinsHemopexinHumansIronNeisseria meningitidisProtozoan ProteinsReceptors, Cell SurfaceStaphylococcus aureusTrypanosoma brucei bruceiBacterial ProteinsCation Transport ProteinsHaptoglobinsHemopexinHpuA protein, NeisseriaIronIsdB protein, Staphylococcus aureusProtozoan ProteinsReceptors, Cell Surfacehemoglobinhemopexiniron piracynutritional immunitypositive selection

Identifiers

PMID30271410
PMCPMC6142043
OpenAlexW2889689905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.