Evidence map›Paper›PMID 30271404›Full record

ArticleFrontiers in immunology2018

CCL3 Promotes Germinal Center B Cells Sampling by Follicular Regulatory T Cells in Murine Lymph Nodes.

Zachary L Benet, Matangi Marthi, Fang Ke, Rita Wu, Jackson S Turner, Jahan B Gabayre, Michael I Ivanitskiy, Sahil S Sethi, Irina L Grigorova

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  3. Targeted checkpoint control of B cells undergoing positive selection in germinal centers by follicular regulatory T cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zachary L BenetDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
Matangi MarthiDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
Fang KeDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
Rita WuDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
Jackson S TurnerDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
Jahan B GabayreDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
Michael I IvanitskiyDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
Sahil S SethiDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
Irina L GrigorovaDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
University of Michigan–Ann Arbor · US

Funding

Dynamic regulation of B cell recruitment in T-dependent humoral immune responseR01AI106806 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GRIGOROVA, IRINA LEONIDOVNA · 2014 to 2017
$1.7M
NIAID NIH HHS R01 AI106806
6 · The paper itself

Abstract

Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity is poorly understood. We found that CCL3 promotes chemotaxis of Tfr cells

Indexed as

Adoptive TransferAnimalsB-LymphocytesCell DifferentiationCells, CulturedChemokine CCL3ChemotaxisGerminal CenterImmunity, HumoralLymph NodesLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutT-Lymphocytes, RegulatoryChemokine CCL32-photon imagingCCL3/MIP1-alphafollicular helper T cellsfollicular regulatory T cells (Tfr)germinal centers

Identifiers

PMID30271404
PMCPMC6146081
OpenAlexW2891804893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.