ArticleFrontiers in aging neuroscience2018
Potential Role of OERP as Early Marker of Mild Cognitive Impairment.
Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Biomarkers for Alzheimer's disease and mild cognitive impairment: Recent advances in task-based EEG.Journal of Alzheimer's disease : JAD · 2026Pooled it
- Functional and effective EEG connectivity patterns in Alzheimer's disease and mild cognitive impairment: a systematic review.Frontiers in aging neuroscience · 2025Pooled it
- Noninvasive Electrophysiological Biomarkers of Olfactory Responses Across Cognitive States in Alzheimer Dementia: Cross-Sectional Study.JMIR mHealth and uHealth · 2026Article
- Characterizing olfaction, anxiety, and depression in subjective cognitive decline.Journal of Alzheimer's disease : JAD · 2026Article
- Integrating olfactory assessments in consciousness disorders: methodologies and therapeutic potential.Frontiers in neurology · 2026Review
- Prejudice, Proxemic Space, and Social Odor: The Representation of the 'Outsider' Through an Evolutionary Metaverse Psychology Perspective.Brain sciences · 2025Article
- Olfactory EEG based Alzheimer disease classification through transformer based feature fusion with tunableFrontiers in neuroscience · 2025Article
- Association between olfactory dysfunction and gustatory dysfunction: evidence from the National Health and Nutrition Examination Survey.Frontiers in public health · 2025Article
- Evaluation of Mild Cognitive Impairment through Perientorhinal/Hippocampal Imaging and Comprehensive Neuropsychological and Psychophysical Assessment.Brain sciences · 2024Article
- Article
- [A prospective study of the effect of functional endoscopic sinus surgery on the recovery of olfactory function in patients with chronic rhinosinusitis with nasal polyposis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023Article
- Exploratory Study on Chemosensory Event-Related Potentials in Long COVID-19 and Mild Cognitive Impairment: A Common Pathway?Bioengineering (Basel, Switzerland) · 2023Article
- Post-traumatic olfactory dysfunction: a scoping review of assessment and rehabilitation approaches.Frontiers in neurology · 2023Article
- Chemosensation in anxiety: the trigeminal system matters.Chemical senses · 2023Article
- Chemobrain, Olfactory and Lifestyle Assessment in Onco-Geriatrics: Sex-Mediated Differences between Chemotherapy and Immunotherapy.Brain sciences · 2022Article
- Spatial Olfactory Memory and Spatial Olfactory Navigation, Assessed with a Variant of Corsi Test, Is Modulated by Gender and Sporty Activity.Brain sciences · 2022Article
- [Application research and development of objective examination of olfactory function].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022Article
- Medicolegal aspect of loss of smell and olfactory event-related potentials.Egyptian journal of forensic sciences · 2022Article
- Electrophysiological and olfactometric evaluation of long-term COVID-19.Physiological reports · 2021Article
- Olfactory Signatures in the Food Finding Test in Mice With Normal and Alzheimer's Disease-Pathological Aging With Special Concerns on the Effects of Social Isolation.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory impairment is present in up to 90% of patients with Alzheimer's disease (AD) and is present in certain cases of mild cognitive impairment (MCI), a transient phase between normal aging and dementia. Subjects affected by MCI have a higher risk of developing dementia compared to the general population, and studies have found that olfactory deficits could be an indicator of whether such a conversion might happen. Following these assumptions, aim of this study was to investigate olfactory perception in MCI patients. We recruited 12 MCI subjects (mean age 70 ± 6.7 years) through the Alzheimer Assessment Unit (UVA Unite) of ASL Lecce (Italy), and 12 healthy geriatric volunteers (HS) as the control group (mean age 64 ± 6.0 years), all of whom were first evaluated via a panel of neuropsychological tests. Subjects were asked to perform an olfactory recognition task involving two scents: rose and eucalyptus, administrated in the context of an oddball task during EEG recordings. Olfactory event-related potential (OERP) components N1 and Late Positive Potential (LPC) were then analyzed as measures of the sensorial and perceptive aspects of the olfactory response, respectively. It was determined that, in the MCI group, both the N1 and LPC components were significantly different compared to those of the HS group during the execution of the oddball task. In particular, the N1 amplitude, was reduced, while the LPC amplitude was increased, indicating that a degree of perceptive compensation can occur when sensorial function is impaired. Further, a correlation analysis, involving OERP components and neuropsychological battery scores, indicated that impairment of olfactory perception may share common pathways with impairments of the spatial system and long-term memory processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.