ArticleFrontiers in behavioral neuroscience2018
The Urge to Fight: Persistent Escalation by Alcohol and Role of NMDA Receptors in Mice.
Article in Frontiers in behavioral neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework.Psychopharmacology · 2026Review
- Independent inhibitory control mechanisms for aggressive motivation and action.Nature neuroscience · 2024Article
- The neutral CB1 antagonist AM6527 reduces ethanol seeking, binge-like consumption, reinforcing, and withdrawal effects in male and female mice.Psychopharmacology · 2024Article
- Excessive alcohol consumption after exposure to two types of chronic social stress: intermittent episodes vs. continuous exposure in C57BL/6J mice with a history of drinking.Psychopharmacology · 2022Article
- To fight or not to fight: activation of the mPFC during decision to engage in aggressive behavior after ethanol consumption in a novel murine model.Psychopharmacology · 2022Article
- Promises and Pitfalls of NMDA Receptor Antagonists in Treating Violent Aggression.Frontiers in behavioral neuroscience · 2022Article
- Neurobiological Bases of Alcohol Consumption After Social Stress.Current topics in behavioral neurosciences · 2022Article
- Organization of neural circuits underlying social behavior: A consideration of the medial amygdala.Current opinion in neurobiology · 2021Review
- Rage Against the Machine: Advancing the study of aggression ethology via machine learning.Psychopharmacology · 2020Review
- The Role of the N-Methyl-D-Aspartate Receptors in Social Behavior in Rodents.International journal of molecular sciences · 2019Review
- Fighting Females: Neural and Behavioral Consequences of Social Defeat Stress in Female Mice.Biological psychiatry · 2019Article
- Animal Models of (or for) Aggression Reward, Addiction, and Relapse: Behavior and Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Review
- Nucleus Accumbens Drd1-Expressing Neurons Control Aggression Self-Administration and Aggression Seeking in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Chronic administration of ketamine ameliorates the anxiety- and aggressive-like behavior in adolescent mice induced by neonatal maternal separation.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2019Article
- Translational models of adaptive and excessive fighting: an emerging role for neural circuits in pathological aggression.F1000Research · 2019Review
- Social defeat stress and escalation of cocaine and alcohol consumption: Focus on CRF.Neurobiology of stress · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Alcohol drinking, in some individuals, culminates in pathologically aggressive and violent behaviors. Alcohol can escalate the urge to fight, despite causing disruptions in fighting performance. When orally administered under several dosing conditions the current study examined in a mouse model if repeated alcohol escalates the motivation to fight, the execution of fighting performance, or both. Specifically, seven daily administrations of alcohol (0, 1.8, or 2.2 g/kg) determined if changes in the motivation to initiate aggressive acts occur with, or without, shifts in the severity of fighting behavior. Responding under the control of a fixed interval (FI) schedule for aggression reinforcements across the initial daily sessions indicated the development of tolerance to alcohol's sedative effect. By day 7, alcohol augmented FI response rates for aggression rewards. While alcohol escalated the motivation to fight, fighting performance remained suppressed across the entire 7 days. Augmented FI responding for aggression rewards in response to a low dose of alcohol (1.0 g/kg) proved to be persistent, as we observed sensitized rates of responding for more than a month after alcohol pretreatment. In addition, this sensitization of motivated aggression did not occur with a general enhancement of motor activity. Antagonism of NMDA or AMPA receptors with ketamine, dizocilpine, or NBQX during later challenges with alcohol were largely serenic without having any notable impact on the expression of alcohol-escalated rates of FI responding. The current dissociation of appetitive and performance measures indicates that discrete neural mechanisms controlling aggressive arousal can be distinctly sensitized by alcohol.
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