ArticleNeuropsychiatric disease and treatment2018
Low hedonic tone and attention-deficit hyperactivity disorder: risk factors for treatment resistance in depressed adults.
Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapies.Molecular psychiatry · 2026Pooled it
- Early or recent trauma in treatment-resistant depression: a systematic review.CNS spectrums · 2025Pooled it
- Understanding antidepressant change patterns in the UK Biobank.The British journal of psychiatry : the journal of mental science · 2026Article
- Blunted anticipation, but not consummation, of food rewards in depression.Cell reports. Medicine · 2026Article
- The effects of psychedelics on attention deficit and hyperactivity disorder - a systematic review.Acta neuropsychiatrica · 2026Review
- Adult ADHD with comorbid major depression shows a distinguishable polygenic pattern and negative cognitive style.Translational psychiatry · 2026Article
- The METOD study: exploring metabolism, emotional blunting and treatment outcomes in depression - A naturalistic, two-phase observational protocol.Frontiers in pharmacology · 2026Article
- Treatment-resistant depression: role of genetic factors in the perspective of clinical stratification and treatment personalisation.Molecular psychiatry · 2025Review
- Longitudinal study on all-cause and suicide mortality among individuals with attention deficit hyperactivity disorder.European child & adolescent psychiatry · 2025Article
- Association between the functional brain network and antidepressant responsiveness in patients with major depressive disorders: a resting-state EEG study.Psychological medicine · 2025Article
- Intolerance of uncertainty, perfectionism, and coping as predictors of depression diagnosis and severity.Journal of mood and anxiety disorders · 2023Article
- Associations between resting state functional brain connectivity and childhood anhedonia: A reproduction and replication study.PloS one · 2023Article
- Mainstreaming adult ADHD into primary care in the UK: guidance, practice, and best practice recommendations.BMC psychiatry · 2022Article
- Orexin/Hypocretin System Dysfunction in ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations).Neuropsychiatric disease and treatment · 2022Article
- Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts.Molecular psychiatry · 2021Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe burdens imposed by treatment-resistant depression (TRD) necessitate the identification of predictive factors that may improve patient treatment and outcomes. Because depression and attention-deficit hyperactivity disorder (ADHD) are frequently comorbid and share a complex relationship, we hypothesized that ADHD may be a predictive factor for the diagnosis of TRD. This exploratory study aimed to determine the percentage of undetected ADHD in those with TRD and evaluate factors associated with treatment resistance and undetected ADHD in depressed patients. SUBJECTS AND
methodsAdults referred (n=160) for psychiatric consultation completed a structured interview (MINI Plus, Mini International Neuropsychiatric Interview Plus) to assess the presence of psychiatric disorders.
resultsTRD was significantly associated with the number of diagnoses (
conclusionUndetected ADHD may be more prevalent among TRD patients than previously thought. In addition, TRD patients are more likely to present with psychiatric comorbidity than non-TRD patients. Screening patients with depression for the presence of ADHD and chronic anhedonia/low hedonic tone may help identify patients with TRD and undetected ADHD and improve treatment outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.