Evidence map›Paper›PMID 30271115›Full record

SynthesisDrug design, development and therapy2018

The role of hypoxia-inducible factor stabilizers in the treatment of anemia in patients with chronic kidney disease.

Hongzhen Zhong, Tianbiao Zhou, Hongyan Li, Zhiqing Zhong

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Drug design, development and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hongzhen ZhongDepartment of Nephrology, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China, zhoutb@aliyun.net.
Tianbiao ZhouDepartment of Nephrology, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China, zhoutb@aliyun.net.
Hongyan LiDepartment of Nephrology, Huadu District People's Hospital of Guangzhou, Southern Medical University, Guangzhou, China.
Zhiqing ZhongDepartment of Nephrology, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China, zhoutb@aliyun.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe purpose of this study was to analyze the effects of hypoxia-inducible factor (HIF) stabilizers on anemia in non-dialysis-dependent (NDD) and dialysis-dependent (DD) chronic kidney disease (CKD) patients.

methodsPublished studies were extracted from PubMed, China Biological Medicine Database (CBM), Wanfang database, and Cochrane Library on March 10, 2018, and relevant studies were pooled and included in a meta-analysis. Data on hemoglobin (Hb), ferritin, and hepcidin levels, total iron-binding capacity (TIBC), and incidence of adverse events (AEs) were extracted and pooled using Review Manager Version 5.3.

resultsData from nine selected studies were extracted. Meta-analysis of the included studies showed that HIF stabilizers reduced ferritin and hepcidin levels and increased Hb level and TIBC in NDD-CKD patients. However, HIF stabilizers only increased TIBC, and did not affect ferritin, hepcidin, and Hb levels in DD-CKD patients. Furthermore, no notable differences in AEs and severe AEs between NDD-CKD and DD-CKD patients were detected.

conclusionHIF stabilizers are effective for the treatment of anemia in NDD-CKD patients and safe for short-term use.

Indexed as

AnemiaAryl Hydrocarbon Receptor Nuclear TranslocatorEnzyme InhibitorsHumansHypoxia-Inducible Factor 1, alpha SubunitHypoxia-Inducible Factor-Proline DioxygenasesProtein StabilityRenal Insufficiency, ChronicAryl Hydrocarbon Receptor Nuclear TranslocatorEnzyme InhibitorsHypoxia-Inducible Factor 1, alpha SubunitHypoxia-Inducible Factor-Proline Dioxygenasesanemiachronic kidney diseasehypoxia-inducible factor stabilizermeta-analysis

Identifiers

PMID30271115
PMCPMC6151102

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.