Evidence map›Paper›PMID 30271019›Full record

ArticleAnnals of pediatric cardiology

Rationale and design of Long-term Outcomes and Vascular Evaluation after Successful Coarctation of the Aorta Treatment study.

Jose D Martins, Justin Zachariah, Elif Seda Selamet Tierney, Uyen Truong, Shaine A Morris, Shelby Kutty, Sarah D de Ferranti, Jonathan Rhodes, Marta Antonio, Maria Guarino and 7 more

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In one paragraph

Article in Annals of pediatric cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jose D MartinsDepartment of Pediatric Cardiology, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.
Justin ZachariahDivision of Pediatric Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, USA.
Elif Seda Selamet TierneyDivision of Pediatric Cardiology, Department of Pediatrics, Lucile Packard Children's Hospital, Stanford University, Palo Alto, USA.
Uyen TruongDivision of Pediatric Cardiology, Children's Hospital Colorado, Aurora, USA.
Shaine A MorrisDivision of Pediatric Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, USA.
Shelby KuttyJoint Division of Pediatric Cardiology, Children's Hospital and Medical Center University of Nebraska College of Medicine, Omaha, USA.
Sarah D de FerrantiDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, USA.
Jonathan RhodesDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, USA.
Marta AntonioDepartment of Pediatric Cardiology, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.
Maria GuarinoCEDOC Chronic Diseases, Nova Medical School, Lisbon, Portugal.
Boban ThomasCaselas, Ressonância Magnética, S. A. Lisbon, Portugal.
Diana OliveiraBiomedical Engineering Department, Instituto Superior Técnico, Lisbon, Portugal.
Kimberlee GauvreauDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, USA.
Nuno JallesCaselas, Ressonância Magnética, S. A. Lisbon, Portugal.
Tal GevaDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, USA.
Miguel CarmoCEDOC Chronic Diseases, Nova Medical School, Lisbon, Portugal.
Ashwin PrakashDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoarctation of the aorta (CoA) can be treated using surgery, balloon angioplasty, or stent implantation. Although short-term results are excellent with all three treatment modalities, long-term cardiovascular (CV) morbidity and mortality remain high, likely due to persistently abnormal vascular function. The effects of treatment modality on long-term vascular function remain uncharacterized. The goal of this study is to assess vascular function in this patient population for comparison among the treatment modalities.

methodsWe will prospectively assess vascular Afunction in large and small arteries fusing multiple noninvasive modalities and compare the results among the three groups of CoA patients previously treated using surgery, balloon angioplasty, or stent implantation after frequency matching for confounding variables. A comprehensive vascular function assessment protocol has been created to be used in 7 centers. Our primary outcome is arterial stiffness measured by arterial tonometry. Inclusion and exclusion criteria have been carefully established after consideration of several potential confounders. Sample size has been calculated for the primary outcome variable.

conclusionTreatment modalities for CoA may have distinct impact on large and small arterial vascular function. The results of this study will help identify the treatment modality that is associated with the most optimal level of vascular function, which, in the long term, may reduce CV risk.

Indexed as

Arterial stiffnesscardiac magnetic resonance imagingcoarctation of the aortalong-term outcomespulse wave velocityvascular function

Identifiers

PMID30271019
PMCPMC6146860

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.