Evidence map›Paper›PMID 30270990›Full record

ArticleSensors and actuators. B, Chemical2018

Lateral Flow Test for Visual Detection of Multiple MicroRNAs.

Wanli Zheng, Li Yao, Jun Teng, Chao Yan, Panzhu Qin, Guodong Liu, Wei Chen

Abstract read
In one paragraph

Article in Sensors and actuators. B, Chemical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wanli ZhengSchool of Food Science & Engineering, Hefei University of Technology, 230009, Anhui, PR China.
Li YaoSchool of Food Science & Engineering, Hefei University of Technology, 230009, Anhui, PR China.
Jun TengSchool of Food Science & Engineering, Hefei University of Technology, 230009, Anhui, PR China.
Chao YanSchool of Food Science & Engineering, Hefei University of Technology, 230009, Anhui, PR China.
Panzhu QinSchool of Food Science & Engineering, Hefei University of Technology, 230009, Anhui, PR China.
Guodong LiuDepartment of Chemistry & Biochemistry, North Dakota State University, Fargo, ND 58105, USA.
Wei ChenSchool of Food Science & Engineering, Hefei University of Technology, 230009, Anhui, PR China.

Funding

Targeting CLEC-2/podoplanin as a therapeutic strategy for pancreatic cancerP20GM109024 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI Megan Orr · 2016 to 2026
$20.5M
NIGMS NIH HHS P20 GM109024
6 · The paper itself

Abstract

The authors describe a rapid and low-cost approach for multiplex microRNA(miRNA) assay on lateral flow nucleic acid biosensor (LFNAB). The principle of assay is based on sandwich-type nucleic acid hybridization reactions to produce gold nanoparticle (GNP)-attached complexes (ssDNA-microRNA-ssDNA/GNPs), which are captured and visualized on the test zone of LFNAB. By designing three different test zones on LFNAB, simultaneous detection of microRNA-21, microRNA-155 and microRNA-210 was achieved with an adding-measuring model by using GNP as visual tag. The method was challenged by testing the microRNAs in spiked serum samples with satisfied results. In our perception, the test is a particularly valuable tool for clinical application and biomedical diagnosis, particularly in limited resource settings.

Indexed as

Lateral flow biosensormicroRNAmultiplex detectionserum samplesimultaneous detection

Identifiers

PMID30270990
PMCPMC6159930

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.