ArticleThe Journal of international medical research2019
High pretreatment plasma D-dimer levels are associated with shorter overall survival in patients with small cell lung cancer.
Article in The Journal of international medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The D-dimer level predicts the prognosis in patients with lung cancer: a systematic review and meta-analysis.Journal of cardiothoracic surgery · 2021Pooled it
- Prognostic value of neuron-specific enolase for small cell lung cancer: a systematic review and meta-analysis.World journal of surgical oncology · 2020Pooled it
- Prognostic Value of Pretreatment D-Dimer Level in Small-Cell Lung Cancer: A Meta-Analysis.Technology in cancer research & treatmentPooled it
- Prognostic value of plasma D-dimer levels in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors: a retrospective study.Journal of thoracic disease · 2022Article
- Circulating D-Dimers Increase the Risk of Mortality and Venous Thromboembolism in Patients With Lung Cancer: A Systematic Analysis Combined With External Validation.Frontiers in medicine · 2022Article
- High pretreatment plasma D-dimer levels predict poor survival in patients with diffuse large B-cell lymphoma in the real world.Translational cancer research · 2021Article
- Diagnostic Value of Serum D-Dimer for Detection of Gallbladder Carcinoma.Cancer management and research · 2021Article
- Clinical characteristics and prognostic analysis of Lung Cancer patients with Hypercoagulability: A single-center, retrospective, real-world study.Journal of Cancer · 2021Article
- Application of an elevated plasma D-dimer cut-off value improves prognosis prediction of advanced non-small cell lung cancer.Annals of translational medicine · 2020Article
- Differential Expression and Diagnostic Significance of Pre-Albumin, Fibrinogen Combined with D-Dimer in AFP-Negative Hepatocellular Carcinoma.Pathology oncology research : POR · 2020Article
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3 authors.
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Abstract
objectiveTo investigate the relationship between pretreatment plasma D-dimer levels and survival in Chinese patients with small cell lung cancer (SCLC).
methodsThis retrospective study enrolled 82 patients with SCLC treated at Beijing Chaoyang Hospital, Capital Medical University, from January 2012 to January 2015. All patients were followed up. Associations between pretreatment plasma D-dimer levels measured by immunoturbidimetric assay and clinical outcomes were analyzed by Kaplan-Meier and multivariate analyses, using a cut-off level of 0.55 mg/L fibrinogen equivalent units (FEU).
resultsMedian progression-free survival (PFS) and overall survival (OS) were significantly higher in patients with low D-dimer levels (≤0.55 mg/L FEU; 8.0 and 17.0 months, respectively) compared with patients with high levels (>0.55 mg/L FEU; 5.0 and 9.0 months, respectively). Plasma D-dimer levels, Karnofsky performance status, N stage, TNM stage, treatment, and neuron-specific enolase (NSE) levels were significantly associated with PFS, while D-dimer levels, N stage, TNM stage, and treatment were significantly associated with OS. Multivariate analysis revealed that TNM stage, treatment, and NSE levels were independently associated with PFS, while D-dimer levels and treatment were independently associated with OS.
conclusionsPretreatment plasma D-dimer levels were independently associated with OS in patients with SCLC.
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