Evidence map›Paper›PMID 30270798›Full record

ArticleThe Journal of international medical research2019

Beraprost sodium versus clopidogrel for preventing vascular thromboembolic events of arteriovenous fistula in uraemic patients: a retrospective study with a mean 3-year follow-up.

Ziming Wan, Ying Zhu, Ruikun Yang, Yongjian Zhang, Chen Yang, Lei Cao, Wenjing Yan, Qi Wang, Ning Li, Mingdong Zhao and 2 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Ziming Wan1 Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, China.
Ying Zhu2 Radiology Department, The First Affiliated Hospital, Sun Yat-sen University, Yuexiu District, Guangzhou, China.
Ruikun Yang3 Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Yuexiu District, Guangzhou, China.
Yongjian Zhang4 Department of Thoracic surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Jianghan District, Wuhan, Hubei, China.
Chen Yang5 Department of Physical Examination, The First Affiliated Hospital, Sun Yat-sen University, Yuexiu District, Guangzhou, China.
Lei Cao6 Department of Anesthesiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Jianghan District, Wuhan, Hubei, China.
Wenjing Yan7 The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Jianghan District, Wuhan, Hubei, China.
Qi Wang6 Department of Anesthesiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Jianghan District, Wuhan, Hubei, China.
Ning Li8 Department of Neurology, The Affiliated Hospital of Hebei University, Baoding, Hebei, China.
Mingdong Zhao9 Department of Orthopaedics, Jinshan Hospital, Fudan University, Jinshan District, Shanghai City, China.
Keke Gui9 Department of Orthopaedics, Jinshan Hospital, Fudan University, Jinshan District, Shanghai City, China.
Min Xiong9 Department of Orthopaedics, Jinshan Hospital, Fudan University, Jinshan District, Shanghai City, China.
Huazhong University of Science and Technology · CNJinshan Hospital of Fudan University · CNSun Yat-sen University · CNAffiliated Hospital of Hebei University · CNCentral Hospital of Wuhan · CNFirst Affiliated Hospital of Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to evaluate the efficacy of beraprost sodium (BPS) or clopidogrel (CL) using vascular thromboembolic events (VTEs) of arteriovenous fistula as a primary endpoint in patients with end-stage renal disease (ESRD) undergoing arteriovenous fistula surgery.

methodsWe performed a multicentre, retrospective cohort study from August 2012 to August 2016. We studied patients with ESRD who underwent arteriovenous fistula surgery and received peroral administration of 40 µg BPS, three times per day, for 1 month, or 75 mg CL (initial dose of 300 mg), one time per day, for 1 month. The time to first on-study VTE was the primary endpoint.

resultsThe BPS-treated cohort had a significantly delayed time to first VTE compared with the CL-treated cohort (hazard ratio 0.33, 95% confidence interval 0.18-0.56). An increased incidence of VTEs was detected in the 1-month follow-up, with rates of 2.4% and 8.7% for BPS and CL, respectively. This difference persisted over time, with rates of 8.0% and 18.1% at the final follow-up, respectively.

conclusionCL-treated patients with ESRD have a greater risk of VTEs compared with BPS-treated patients. CL-treated patients also tend to experience a VTE within the first month after cessation of oral administration.

Indexed as

Renal DialysisAdministration, OralAdultArteriovenous FistulaClopidogrelDrug Administration ScheduleEpoprostenolFemaleFollow-Up StudiesHumansKidney Failure, ChronicMaleMiddle AgedPlatelet Aggregation InhibitorsRetrospective StudiesUremiaberaprostClopidogrelEpoprostenolPlatelet Aggregation Inhibitorsarteriovenous fistulaBeraprost sodiumclopidogrelend-stage renal diseaseuraemiavascular thromboembolic event

Identifiers

PMID30270798
PMCPMC6384486
OpenAlexW2894682786

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.