Evidence map›Paper›PMID 30270704›Full record

ArticleInternational journal of immunopathology and pharmacology

Marina crystal minerals (MCM) activate human dendritic cells to induce CD4+ and CD8+ T cell responses in vitro.

Mamdooh H Ghoneum, Takeshi Ogura, James K Gimzewski, Aya D Ghoneum, Michael C Henary, Sudhanshu Agrawal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Mamdooh H Ghoneum1 Department of Surgery, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
Takeshi Ogura2 Kaiyo Kagaku Co., Ltd., Tokyo, Japan.
James K Gimzewski3 Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Aya D Ghoneum3 Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Michael C Henary5 Department of Psychology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Sudhanshu Agrawal6 Division of Basic and Clinical Immunology, University of California, Irvine (UCI), Irvine, CA, USA.
University of California, Los Angeles · USCalifornia NanoSystems Institute · USCharles R. Drew University of Medicine and Science · USRiso Kagaku (Japan) · JPUniversity of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Marina crystal minerals (MCM) are a mixture that contains crystallized minerals along with trace elements extracted from seawater. It is a nutritional supplement that is capable of enhancing natural killer (NK) cell activity and increasing T and B cell proliferation in humans post ingestion. However, its effect on dendritic cells (DCs), the cells that bridge innate and adaptive immunity, is not yet known. In this study, we examine the stimulatory effects of MCM on DCs' maturation and function in vitro. Human monocyte-derived DCs were treated with MCM at two different concentrations (10 and 20 µg/mL) for 24 h. Results showed that MCM treatment activated DCs in a dose-dependent fashion. It caused the upregulation of costimulatory molecules CD80, CD86, and HLA-DR, and prompted the production of DC cytokines, including interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, and IL-1β, and chemokines (monocyte chemotactic protein-1 (MCP-1)) and interferon-gamma-inducible protein-10 (IP-10). In addition, activated DCs primed CD4+ T cells to secrete significant amounts of interferon gamma (IFN-γ), and they also stimulated CD8+ T cells to express higher amounts of CD107a. These results indicate that MCM is a potentially powerful adjuvant, from natural materials, that activates human DCs in vitro and therefore may suggest its possible use in immune-based therapies against cancer and viral infections.

Indexed as

Lymphocyte ActivationAdjuvants, ImmunologicB7-1 AntigenB7-2 AntigenCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedCoculture TechniquesCrystallizationCytokinesDendritic CellsHLA-DR AntigensHumansLysosomal-Associated Membrane Protein 1MineralsParacrine CommunicationAdjuvants, ImmunologicB7-1 AntigenB7-2 AntigenCD86 protein, humanCytokinesHLA-DR AntigensLysosomal-Associated Membrane Protein 1MineralsCD4+ T cellsCD8+ T cellsDCsMCM

Identifiers

PMID30270704
PMCPMC6168724
OpenAlexW2895497111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.