Evidence map›Paper›PMID 30270489›Full record

Trial reportPediatric blood & cancer2019

Hope and benefit finding: Results from the PRISM randomized controlled trial.

Abby R Rosenberg, Miranda C Bradford, Krysta S Barton, Nicole Etsekson, Elizabeth McCauley, J Randall Curtis, Joanne Wolfe, K Scott Baker, Joyce P Yi-Frazier

Abstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatric blood & cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Abby R RosenbergCenter for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, Washington.ORCID 0000-0002-7608-607X
Miranda C BradfordCenter for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, Washington.
Krysta S BartonCenter for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, Washington.
Nicole EtseksonCenter for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, Washington.
Elizabeth McCauleyCenter for Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, Washington.
J Randall CurtisDivision of Pulmonary, Critical Care, and Sleep Medicine, Harborview Medical Center, Seattle, Washington.
Joanne WolfeDepartment of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, Massachusetts.
K Scott BakerCenter for Cancer and Blood Disorders, Seattle Children's Hospital, Seattle, Washington.
Joyce P Yi-FrazierCenter for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, Washington.
Seattle Children's Hospital · USBoston Children's Hospital · USUniversity of Washington · US

Funding

NCCIH Supplement to NCATS/CTSA Program for KL2 Scholars - M. SoddersKL2TR002317 · NCATS · UNIVERSITY OF WASHINGTON · PI Christy Michelle McKinney · 2017 to 2026
$14.5M
Institute of Translational Health SciencesKL2TR000421 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$12.6M
NCATS NIH HHS KL2 TR000421NCATS NIH HHS KL2TR000421NCATS NIH HHS KL2 TR002317
6 · The paper itself

Abstract

backgroundAdolescents and young adults (AYAs) with cancer are at risk for poor psychosocial outcomes, perhaps because they have not acquired skills to navigate the adversities of illness. In a recent phase II randomized controlled trial (RCT), the "Promoting Resilience in Stress Management" (PRISM) intervention was associated with improved patient-reported resilience, quality of life, and distress. In this planned analysis of secondary aims, we hypothesized PRISM would also improve targeted coping skills of hopeful thinking, benefit finding, and goal setting.

methodsWe conducted this parallel RCT at Seattle Children's Hospital from January 2015 to October 2016. English-speaking AYAs (12-25 years old) with cancer were randomized one-to-one to PRISM or usual care (UC). PRISM teaches stress-management, goal-setting, cognitive-reframing, and meaning-making skills in four sessions delivered in-person every other week. Participants completed surveys at enrollment and 6 months later. Mixed effects linear regression models evaluated associations between PRISM and benefit finding (Benefit-Finding Scale for Children), hopeful thinking (Hope Scale), and an exploratory outcome of goal setting (queried with open-ended items about participant's goals, measured qualitatively by three blinded reviewers).

resultsOf N = 92 AYAs (48 PRISM, 44 UC), 73% were 12-17 years old, 43% female, and 62% diagnosed with leukemia or lymphoma. PRISM was associated with improved benefit finding and hope with moderate-to-large effect sizes-benefit finding: +3.1 points, 95% CI 0.0, 6.2, d = 0.4, and P = 0.05; and hope: +3.6 points, 95% CI 0.7, 6.4, d = 0.6, and P = 0.01. We did not detect changes in goal setting (-0.5 points, 95% CI -1.2, 0.3, d = -0.3, P = 0.23).

conclusionsPRISM was associated with improvements in benefit finding and hopeful thinking, two adaptive coping skills which may mitigate long-term psychosocial risk.

Indexed as

Adaptation, PsychologicalPsychotherapyResilience, PsychologicalAdolescentAdultChildCounselingFemaleFollow-Up StudiesHumansMaleNeoplasmsPatient Education as TopicPrognosisQuality of LifeStress, Psychologicaladolescent/young adultcancerhealth servicesinterventionpalliative carepatient-reported outcomespositive psychologyquality of lifeRCTresilience

Identifiers

PMID30270489
PMCPMC6249081
OpenAlexW2895350015

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.