Evidence map›Paper›PMID 30270362›Full record

ReviewMetallomics : integrated biometal science2019

Metal-dependent hormone function: the emerging interdisciplinary field of metalloendocrinology.

Michael J Stevenson, Kylie S Uyeda, Nathaniel H O Harder, Marie C Heffern

Abstract readReview
In one paragraph

Review in Metallomics : integrated biometal science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael J StevensonDepartment of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA. mcheffern@ucdavis.edu.
Kylie S Uyeda
Nathaniel H O Harder
Marie C Heffern

Funding

Supplement: Metalloendocrinology: Mapping Bioinorganic Chemistry in the Extracellular SpaceR35GM133684 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HEFFERN, MARIE C. · 2019 to 2023
$2.0M
NIGMS NIH HHS R35 GM133684
6 · The paper itself

Abstract

For over 100 years, there has been an incredible amount of knowledge amassed concerning hormones in the endocrine system and their central role in human health. Hormones represent a diverse group of biomolecules that are released by glands, communicate signals to their target tissue, and are regulated by feedback loops to maintain organism health. Many disease states, such as diabetes and reproductive disorders, stem from misregulation or dysfunction of hormones. Increasing research is illuminating the intricate roles of metal ions in the endocrine system where they may act advantageously in concert with hormones or deleteriously catalyze hormone-associated disease states. As the critical role of metal ions in the endocrine system becomes more apparent, it is increasingly important to untangle the complex mechanisms underlying the connections between inorganic biochemistry and hormone function to understand and control endocrinological phenomena. This tutorial review harmonizes the interdisciplinary fields of endocrinology and inorganic chemistry in the newly-termed field of "metalloendocrinology". We describe examples linking metals to both normal and aberrant hormone function with a focus on highlighting insight to molecular mechanisms. Hormone activities related to both essential metal micronutrients, such as copper, iron, zinc, and calcium, and disruptive nonessential metals, such as lead and cadmium are discussed.

Indexed as

AnimalsBiocatalysisEndocrine GlandsEndocrine System DiseasesHormonesHumansMetalsMicronutrientsHormonesMetalsMicronutrients

Identifiers

PMID30270362
PMCPMC10249669

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.